中药靶向制剂的研究进展Advances on the research of targeted drug system for traditional Chinese medicine
于佳,范青
YU Jia,FAN Qing(Department of Pharmacy
摘要(Abstract)：
目的对中药靶向制剂研究进行了综述。方法查阅21篇文献,对靶向制剂的分类与作用特点,中药靶向制剂的研究进展进行了分别综述。结果靶向制剂可以选择性地作用于靶组织,并提高其药理作用强度和降低全身的不良反应,是一种比较理想的给药方式。但中药靶向制剂还处在基础研究阶段,其研究主要是单一有效成分,复方制剂很少。因为目前的靶向给药系统的设计、制备和质量评价理论适用于单一成分的药物,不适合于成分繁多、理化性质复杂的中药。因此,应首先选择药味较少、作用显著、著名中药复方来作为中药复方靶向制剂研究的突破口。结论中药靶向制剂将成为中药制剂的一个重要发展方向。
Targeted drug system can selectively be functioned in target tissues,which is a good way of administration,because it makes the pharmacologic action stronger and makes the systematic adverse effect lower.But targeted drug system for traditional Chinese medicine is still in the basic research stage.This paper overview the studies about targeted drug system of traditional Chinese medicine,targeted drug system for traditional Chinese medicine will be an important development direction of Chinese medicine preparation.
关键词(KeyWords)：
中药;靶向制剂;微球;脂质体;乳剂
traditional Chinese medicine;targeted drug system;microsphere;liposome;emulsions
基金项目(Foundation):
作者(Author):
于佳,范青
YU Jia,FAN Qing(Department of Pharmacy
参考文献(References)：
- [1]崔福德.药剂学[M].北京:人民卫生出版社,2004:415.
- [2]张兆旺.中药药剂学[M].北京:中国中医药出版社,2003:508.
- [3]袁泉,李馨儒,王会娟,等.水飞蓟素微乳大鼠在体小肠吸收的动力学[J].药学学报,2004,39(8):631-634.
- [4]KANG B K,LEE J S,CHON SK,et al.Development ofself-microe-mulsifying drug delivery systems(SMEDDS)for oral bioavailability enhancement of sim-vastatin in beagle dogs[J].Int J Pharm,2004,274(1-2):65-73.
- [5]CHEN H,CHANG X,WANG T,et al.A study of mi-croemulsion systems for transdermal delivery of triptol-ide[J].J Control Release,2004,98(3):427-436.
- [6]GUPATRR,JAIN SK,ARSHNEY M1.Water-in-oilmicroemulsions as a penetration enhancer in transderaldrug delivery of 5-fluorouracil[J].ColloidsSurfB:Biointerfaces,2005,41(1):25-32.
- [7]王新春,侯世祥,阳长明,等.大黄复方液体喷雾剂中挥发油微乳与相图的应用[J].中成药,2004,26(3):178-181.
- [8]张宁,范青,吕慧怡,等.丹参酮微乳的制备及其质量评价[J].中国中药杂志,2003,28(11):1081-1082.
- [9]张莉,向东,洪诤,等.肝靶向去甲斑蝥素微乳的研究[J].药学学报,2004,39(8):650-655.
- [10]张灵芝.脂质体制备及其在生物医学中的应用[M].北京:北京医科大学、中国协和医科大学联合出版社,1998:1.
- [11]MANAGIT C,KAWAKAI S,NISHIKAWA M,et a1.Targeted and sustained drug delivery using PEGylatedgalactosylated liposomes[J].Int J Pharm,2003,266(1-2):77-84.
- [12]XU L,PRIOLLO KF,CHANG EH.Transferrin-lipo-some-mediated p53 sensitization of squamous cell car-cinoma of the head and neck to radiationin vitro[J].Hum Gene Ther,1997,8(4):467-475.
- [13]STATHOPOULOS G P,BOULIKAS T,KOURVETARISA,et al.Liposomal oxaliplatin in the treatment of ad-vanced cancer:a phaseⅠstudy[J].Anticancer Res,2006,26(2B):1489-1493.
- [14]程国华,罗佳波.汉防己甲素聚乳酸微球小鼠肺靶向研究[J].中国药房,2005,16(6):4181.
- [15]李岩,孙殿甲,杨永新,等.盐酸去氢骆驼蓬碱肝动脉栓塞微球处方工艺研究[J].新疆医科大学学报,2003,26(2):109.
- [16]戴卫红,丛月珠.复方黄连解毒微囊的制备[J].中国中医急症,2004,13(4):242.
- [17]GAUR U,SAHOO SK,DE TK,et al.Biodistribution offluoreseinated dextran using novel nanoparticles eva-ding reticuloendothelial system[J].int J Pharm,2002,202(1-2):1.
- [18]MITRA S,GAUR U,GHOSH PC,et al.Tunour targe-ade delivery of encapsulated dextran-doxrubicin con-jugate using chitonsan manoparticles as carrier[J].JCntrolled Release,2001,74(1-3):317.
- [19]MOSQUEIRA VC,LEGRAND P,GREF R,et al.Inter-actions between a macrophage cell line(J774A1)andsurface-modified pol(D,L-lactide)nanocapsulesbearing poly(ethylene glycol)[J].J Drug Target,1999,7(1):65.
- [20]向娟娟,朱诗国,吕红斌,等.用氧化铁磁性纳米颗粒作为基因载体的研究[J].癌症,2001,20(10):1009.
- [21]何军,奉建芳,蔡本琴,等.口服水飞蓟素固体脂质纳米粒(SM-SLN)肝靶向性的动物实验研究[J].高技术通讯,2005,9(5):71-75.