孙彦君,陈虹,华会明
SUN Yan-jun1,2,CHEN Hong3

• 1:河南中医学院药学院
• 2:沈阳药科大学基于靶点的药物设计与研究教育部重点实验室
• 3:武警医学院生药教研室

摘要(Abstract)：

目的对鬼臼毒素衍生物的研究概况进行综述,为鬼臼毒素衍生物的深入研究提供依据。方法通过阅读近5年来29篇相关文献报道,从鬼臼毒素衍生物的抗癌作用机制、合成、构效关系等方面对其目前的研究概况进行综述。结果鬼臼毒素衍生物的合成目前仍以鬼臼毒素C4位修饰为主,最新的文献研究表明与C4位有含氧取代基的鬼臼毒素衍生物相比,相应位置没有取代基的鬼臼毒素类似物细胞毒活性更强。结论为鬼臼毒素衍生物的合成提供参考数据。
Objective To review the researches on the podophyllotoxin derivatives,and provide the basis for its further research.Methods Papers published mainly in the recent 5 years had been reviewed including anticancer mechanism,synthesis,and structure-activity relationship.Results Most of research efforts have been focused on exploring different 4-substituted podophyllotoxin analogues.Podophyllotoxin analogues with 4 oxygenated group exhibited significantly lower cytotoxic activity than corresponding analogues without 4-substitution.Conclusions This review provides a useful reference for the synthesis of podophyllotoxin derivatives.

关键词(KeyWords)： 鬼臼毒素衍生物;抗肿瘤作用机制;合成;构效关系
podophyllotoxin derivative;anticancer mechanism;synthesis;strucure-activity relationship

Abstract:

Keywords:

基金项目(Foundation): 河南中医学院博士科研启动基金(BSJJ2011-13)

作者(Author): 孙彦君,陈虹,华会明
SUN Yan-jun1,2,CHEN Hong3

DOI: 10.14066/j.cnki.cn21-1349/r.2012.12.011

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