口服结肠定位给药系统The oral colon-specific drug delivery system
邹梅娟,程刚
ZOU Mei juan; CHENG Gang (College of Pharmacy;
摘要(Abstract):
综述了近年来口服结肠定位给药系统的发展状况 ,并评价了各类结肠定位给药系统的优、缺点和发展前景
This article provides a review of technologies available for oral colon specific drug delivery mainly including the bacterially triggered delivery system, pH dependent delivery system and time dependent delivery system.
关键词(KeyWords):
结肠定位释药;细菌激活释药系统;pH依赖释药系统;时间依赖释药系统
oral colon specific drug delivery;bacterially triggered delivery system;pH dependent delivery system;time dependent delivery system
基金项目(Foundation): 辽宁省自然科学基金资助项目 (991 0 5 0 0 5 0 4 )
作者(Authors):
邹梅娟,程刚
ZOU Mei juan; CHENG Gang (College of Pharmacy;
参考文献(References):
- [1]WattsPeterJ,IlluLisbethm.Thecolonicdeliverysys tem[J].DrugDevPharmInd,1997,23(9):893-913.
- [2]DavaranSoodabeh,HamaeeJalal,KhosraviAbbas.Re leaseof5ASAfromacrylictypepolymericprodrugsdesignedforcolon specificdrugdelivery[J].JCon trolledRelease,1999,58:279-287.
- [3]SchachtEtienne,GevaertAn,KenawyElRefaie,etal.Polymersforcolonspecificdrugdelivery[J].JControlledRelease,1996,(39):327-338.
- [4]周宇.口服结肠定位给药系统[J].国外医药:药学分册,1999,26(4):225-229.
- [5]ZahirulM ,KhanI,HelenaP ,etal.ApH dependentcolon targetedoraldrugdeliverysystemusingMethacrylicacidcopolymers.II.ManipulationofdrugreleaseusingEudragitL100andEudragitS100combi nations[J].DrugDevIndPharm,2000,26(5):549-554.
- [6]GazzanigaA ,IamartinoP ,MaffioneG ,etal.Oraldelayed releasesystemforcolonicspecificdelivery[J].IntJPharm,1994,108:77-84.
- [7]平其能.现代药剂学[M].北京:中国医药科技出版社,1998.
- [8]张静,平其能.口服择时释药系统[J].药学进展,1999,23(5):265-268.
- [9]PozziF ,FurlaniP ,GazzanigaA ,etal.Thetimeclocksystem:aneworaldosageformforfastandcom pletereleaseofdrugafterapredeterminedlagtime[J].JControlledRelease,1994,31:99.
- [10]陆彬.药物新剂型与新技术[M].北京:人民卫生出版社,1998.
- [11]ConteU ,ColomboP ,MannaAI,etal.Anewibuprofenpulsedreleaseoraldosageform[J].DrugDevIndPharm,1989,15(14-16):2583.
- [12]TakashiIshibashi,KengoIkegami.Thetime controlleddrugdeliverysystem[J].JControlledRelease,1999,59(3):361-376.
- [13]RacSS,RitschelWA .Developmentandinvitro/invivoevaluationofacolonicdeliverycapsuleofvaso pressin[J].IntJPharm,1992,86:35-41.
- [14]SemdeRasmane,AmighiKarim,DevleeschouwerMichelJ.StudiesofHM/EudragitRL/EudragitNEfilm coatingformulationsintendedforcolonicdrugde livery[J].IntJPharm,2000,197:181-192.
- [15]NatisawaShiji,NagataNinako,DanyoshiChieko.Anorganicacid inducedsigmoidalreleasesystemfororalcontrolled release preparations[J].PharmRes,1994,11(1):111-116.
- [16]MuraokaM ,HuZ ,ShimokawaT ,etal.Evaluationofintestinalpressure controlledcolondeliverycapsulecontainingcaffeineasamodeldruginhumanvolun teers[J].JControlledRelease,1998,52(1/2):119-129.
- [17]NakaseHiroshi,OkazakiKazuichi,TabataYasuhiko.Developmentofanoraldrugdeliverysystemtargetingimmune regulatingcellsinexperimentalinflammmma toryboweldisease:anewtherapeutic[J].JPharmExpTher,2000,292(1):15-21.
- 结肠定位释药
- 细菌激活释药系统
- pH依赖释药系统
- 时间依赖释药系统
oral colon specific drug delivery - bacterially triggered delivery system
- pH dependent delivery system
- time dependent delivery system