张颖,张起辉,王光函,陈晓辉,康廷国,毕开顺
ZHANG Ying1,2,ZHANG Qi-hui1,WANG Guang-han2,CHEN Xiao-hui1,KANG Ting-guo3

• 1:沈阳药科大学中药学院
• 2:辽宁省中医药研究院
• 3:辽宁中医药大学药学院

摘要(Abstract)：

目的建立枣仁安神颗粒HPLC指纹图谱,研究酸枣仁、丹参、五味子药材与复方指纹图谱的相关性。方法应用HPLC-DAD检测方法 ,建立枣仁安神颗粒的指纹图谱,以色谱峰保留时间相对偏差Δt和紫外光谱相似性为考察指标,对复方指纹图谱色谱峰归属进行分析。结果共得到23个色谱峰,确定了特征峰的药材归属,指认了其中9个化学成分。结论所建立的指纹图谱特征性强,明确了复方色谱指纹图谱的峰位归属,为进一步的谱效研究奠定基础。
Objective To establish HPLC fingerprint of Zaorenanshen granules(traditional Chinese medicine)and correlativity analysis between fingerprint peaks of compound recipe and its relevant herbs.Methods The chromatographic fingerprints of compound recipe and the relevant herbs were configured by HPLC-DAD analysis.The relative deviation △t of retention time and the similarity of UV spectra of peaks were used as indices to evaluate the correlativity.Results Twenty-three common peaks were separated from compound recipe,of which 9 peaks were identified.Conclusions The method is stable and reliable and can make the initial judgment for the correlativity between compound recipe and its relevant herbs.This will provide a reference for the relationship between fingerprint peaks and pharmacodynamics.

关键词(KeyWords)： 枣仁安神颗粒;指纹图谱;相关性
Zaorenanshen granule;fingerprint peak;correlativity

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张颖,张起辉,王光函,陈晓辉,康廷国,毕开顺
ZHANG Ying1,2,ZHANG Qi-hui1,WANG Guang-han2,CHEN Xiao-hui1,KANG Ting-guo3

DOI: 10.14066/j.cnki.cn21-1349/r.2010.10.001

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