刘苗,吴静生,孙华屹,刘铮,赵剑,杨月明
LIU Miao1,WU Jing-sheng1,SUN Hua-yi2,LIU Zheng1,ZHAO Jian1,YANG Yue-ming1 (1.School of Life Science and Biopharmaceutics

• 1:沈阳药科大学生命科学与生物制药学院
• 2:中国医科大学

摘要(Abstract)：

目的研究复方果胶铋(compound colloidal bismuth pectin,CCBP)的抗幽门螺旋杆菌及治疗实验动物胃溃疡作用。方法采用幽门螺旋杆菌诱导的BALB/c小鼠和沙土鼠胃溃疡模型,灌胃给予不同剂量的复方果胶铋。结果结果显示复方果胶铋720、2 160 mg.kg-1组对上述胃溃疡模型动物均具有降低溃疡指数的作用,抑制率呈现剂量效应相关性,随剂量增加效果增强。复方果胶铋530、1 600 mg.kg-1、复方枸橼酸铋甲硝唑四环素(bismuth subcitrate potassium,metronidazole,and tet-racycline hydrochloride,简称PYLERA)组沙土鼠胃组织尿素酶活性比模型组显著降低,其中1 600 mg.kg-1组动物的体内抑菌率为65.1%。结论复方果胶铋对各种胃溃疡模型实验动物胃黏膜损伤有明显保护作用。同剂量比较复方果胶铋降低溃疡指数效果优于各单方,与市售抗溃疡药PYLERA作用相当。
Objective To investigate the effects of compound colloidal bismuth pectin(CCBP) on anti Helicobacter pylori activity and treatment of gastric ulcer for laboratory animals.Methods The BALB/c mice and gerbil gastric ulcer models induced by Helicobacter pylori were applied in this study to investigate the pharmacodynamics in vivo and the animals were given different doses of CCBP by oral administration.Results The results showed that CCBP 720,2 160 mg·kg-1 groups had an effect of reducing the ulcer index on gastric ulcer model animals.The inhibition rate showed a dose-effect relationship and the effect was enhanced as the dose increased.Gerbil gastric tissue urease activity in CCBP 530,1 600 mg·kg-1,bismuth subcitrate potassium,metronidagole,and tetracycline hydrochloride(PYLERA) group was significantly lower than that the model group,in which 1 600 mg·kg-1 group of gerbils in vivo inhibition rate was 65.1%.Conclusions CCBP has a protective effect on various experimental animal models for gastric mucosal damage.The effect of CCBP on reducing the ulcer index is better than other unilateral preparations at the same dose and it might be as good as the antiulcer drug PYLERA.

关键词(KeyWords)： 复方果胶铋;幽门螺旋杆菌;抑菌作用;胃溃疡
compound colloidal bismuth pectin;Helicobacter pylori;bacteriostasis;ulcer

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘苗,吴静生,孙华屹,刘铮,赵剑,杨月明
LIU Miao1,WU Jing-sheng1,SUN Hua-yi2,LIU Zheng1,ZHAO Jian1,YANG Yue-ming1 (1.School of Life Science and Biopharmaceutics

DOI: 10.14066/j.cnki.cn21-1349/r.2010.08.014

参考文献(References)：

• [1]江华.“溃宁”口服液对HP感染后沙土鼠自由基清除作用的实验研究[J].成都中医药大学学报,2003,26(1):46-49.
• [2]伍参荣,彭程,郭春秀,等.戊己丸水煎液对幽门螺旋杆菌感染小鼠体内NO含量的影响[J].中医药导报,2006,12(1):64-66.
• [3]朱国琴.胃黏膜保护剂的研究进展[J].国际消化病杂志,2006,26(5):311-313.
• [4]MEGRAUD F,LAMOULIATTE H.The treatment of re-fractory Helicobacter pylori infection[J].Aliment Phar-maco Ther,2003,17:1333-1343.
• [5]桑青,韩宝芹,刘万顺,等.羧甲基壳聚糖铋盐抗大鼠胃溃疡及杀灭幽门螺旋杆菌作用的研究[J].高技术通讯,2004,7:93-96.
• [6]ZHANG Li-hong,YAO Chang-bai,GAO Ming-qi,et al.Gastric mucosal injury due to hemorrhagic reperfusionand efficacy of Salvia miltiorrhizae extract F and cimeti-dine[J].World J Gastroenterol,2005,11(18):2830-2833.
• [7]OKABE S,AMAGASE K.An overviewof acetic acid ul-cer models-the history and state of the art of peptic ul-cer research[J].Biol Pharm Bull,2005,28:1321-1341.