王中彦,唐星,张向荣,姚家元,孙涛
WANG Zhong yan 1; TANG Xing 1; ZHANG Xiang rong 1; YAO Jia yuan 2; SUN Tao 2 (1 School of Pharmacy;

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院
• 3:沈阳药科大学药学院
• 4:沈阳药业股份有限公司

摘要(Abstract)：

目的制备硝苯地平阿替洛尔缓释胶囊并考察其中硝苯地平体外释放规律。方法通过均匀设计优化出硝苯地平缓释片的处方 ,并用Higuchi释药模式对硝苯地平的体外释放规律进行分析。结果硝苯地平片处方为硝苯地平 2 0mg,聚乙烯吡咯烷酮 1 0mg,羟丙基甲基纤维素 (HPMCK4M)1 0mg,乳糖 1 0mg。在此基础上制备出硝苯地平阿替洛尔缓释胶囊 ,即硝苯地平小片与阿替洛尔颗粒装制胶囊。结论硝苯地平小片符合Higuchi释药模式 ,硝苯地平累积释放百分率在 1、2、4、8h时分别在 1 5 %～ 2 5 %、2 5 %～ 4 5 %、4 5 %～ 80 %和 70 %以上。
Objectine To prepare nifedipine and atenolol sustained release capsules and investigate the release regularity of nifedipine in viro .Methods The recipe of a nifedipine sustained release tablet was selected by employing the uniform design.And the release regularity of nifedipine in vitro was analyzed by empolying the Higuchi release model.Result The recipe of nifedipine sustained release tablets was 20 mg of nifedipine,10 mg of PVP, 10 mg of HPMC K 4M , 10 mg of lactose.Nifedipine and atenolol sustained release capsules were prepared by filling nifedipine tablet and atenolol particles in the same capsule.Conclusion The results indicated that the preparation had the excellent character of Higuchi.The accumulative release of nifedipine was 15%～25%,25%～45%,45%～80% and over 70% in 1,2,4 or 8 h.

关键词(KeyWords)： 硝苯地平;阿替洛尔;缓释胶囊;均匀设计;释放度
uniform design; nifedipine; atenolol; sustained release capsules

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 王中彦,唐星,张向荣,姚家元,孙涛
WANG Zhong yan 1; TANG Xing 1; ZHANG Xiang rong 1; YAO Jia yuan 2; SUN Tao 2 (1 School of Pharmacy;

参考文献(References)：

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