龚成,何仲贵,孙进
GONG Cheng,HE Zhong-gui,SUN Jin(School of Pharmacy

• 1:沈阳药科大学药学院

摘要(Abstract)：

目的从淋巴靶向方面综述脂质体、纳米活性炭以及纳米碳管纳米粒的研究进展。方法参考近年来32篇相关的中外文献,在淋巴系统的生理基础上,探讨上述纳米粒的淋巴靶向性及其在淋巴靶向方面的应用。结果脂质体具有天然的淋巴靶向性。纳米活性炭有较好的淋巴趋向性,并能在淋巴结处缓缓释放出药物。纳米碳管可通过表面修饰来提高其淋巴靶向性。上述纳米粒均可以作为显影剂与药物载体以提高其淋巴靶向性。结论纳米粒有较好的淋巴靶向性,可以作为显影剂和药物靶向淋巴的理想载体。
Objective To review the progresses of the targeting ability to lymphatic system for nanoparticles,including liposomes,activated carbon nanoparticles and carbon nanotubes.Methods According to 32 related literatures,the ability and further application of lymph targeting for nanoparticles were summarized based on the physiological features of lymphatic system.Results Liposomes had natural lymphatic targeting ability.Activated carbon nanoparticles had distinct tropism for lymph and could slowly release the drug in the lymph nodes.Carbon nanotubes had large surface area which can be modified to enhance its tendency to lymphatics.The nanoparticles mentioned above could be carriers for both contrast agents and drugs to target lymphatic system.Conclusions Nanoparticles have the capacity to target lymph and it is an ideal vehicle for contrast agents or drugs to arrive at lymphatic system.

关键词(KeyWords)： 纳米粒;淋巴靶向;淋巴显影;药物靶向淋巴载体
nanoparticle;lymphatic targeting;lymphography;drug carriers

Abstract:

Keywords:

基金项目(Foundation): 国家辽宁(本溪)新药孵化基地建设项目(2010ZX09401-304);; 辽宁“百千万人才工程”人选资助项目(2008921027);; 国家自然科学基金资助项目(81173008)

作者(Author): 龚成,何仲贵,孙进
GONG Cheng,HE Zhong-gui,SUN Jin(School of Pharmacy

DOI: 10.14066/j.cnki.cn21-1349/r.2012.06.014

参考文献(References)：

• [1]平其能.纳米药物制剂的现在和将来[J].中国药师,2000,5(7):421-423.
• [2]FARAJI A H,WIPF P.Nanoparticles in cellular drugdelivery[J].Bioorg Med Chem,2009,17(8):2950-2962.
• [3]格普塔,康佩拉.纳米粒给药系统[M]//孙进,王永军,译.北京:科学出版社,2011:125.
• [4]岳利民,崔慧先.人体解剖生理学[M].5版.北京人民卫生出版社,2007:128-130.
• [5]王怀经,孙保德,胡继康.淋巴系统的解剖与生理[J].实用外科杂志,1993,13(2):69-72.
• [6]邹仲之.组织学与胚胎学[M].5版.北京:人民卫生出版社,2002:126-137.
• [7]SWARTZ M A.The physiology of the lymphatic sys-tem[J].Adv Drug Deliv Rev,2001,50(1/2):3-20.
• [8]FORSSEN E A,TKES Z A.Improved the rapeuticbenefits of doxorubicin by entrapment in anionic lipo-somes[J].Cancer Res,1983,43:546-550.
• [9]OUSSOREN C,VELINOVA M,SCHERPHOF G,etal.Lymphatic uptake and biodistribution of liposomesafter subcutaneous injection:IV.Fate of liposomes inregional lymph nodes[J].Biochim Biophys Acta,1998,1370(2):259-272.
• [10]LING S S N,MAGOSSO E,KARIM N A,et al.En-hanced oral bioavailability and intestinal lymphatictransport of a hydrophilic drug using liposomes[J].Drug Dev Ind Pharm,2006,32(3):335-345.
• [11]邓清明.脂质体阿霉素对淋巴瘤抑制模型的治疗效果[J].中国现代医药杂志,2009,11(11):70-71.
• [12]李晓军,凌瑞,王岭,等.局部注射多柔比星脂质体抑制乳腺癌模型腋窝淋巴结转移癌细胞增殖[J].中华肿瘤防治杂志,2006,13(19):1457-1460.
• [13]蔡云,彭彦,陈邦银,等.香菇多糖脂质体与注射剂对正常小鼠免疫效应的比较[J].中国医院药学杂志,2009,29(19):1624-1627.
• [14]马建忠,侯朝福,张有成,等.淋巴造影剂专利蓝脂质体的制备及其生物学表征[J].国际外科学杂志,2010,37(6):380-382.
• [15]TRUBETSKOY V S,CANNILLO J A,MILSHTEINA,et al.Controlled delivery of Gd-containing lipo-somes to lymph nodes:surface modification may en-hance MRI contrast properties[J].Magn Reson Ima-ging,1995,13(1):31-37.
• [16]WANG M,THANOU M.Targeting nanoparticles tocancer[J].Pharmacol Res,2010,62(2):90-99.
• [17]PARK J W,HONG Kee-lung,KIRPOTIN D B,et al.Anti-HER2 immunoliposomes:enhanced efficacy at-tributable to targeted delivery[J].Clin Cancer Res,2002,8:1172-1181.
• [18]YEON C H,PEGRAM M D.Anti-erbB-2 antibodytrastuzumab in the treatment of HER2-amplifiedbreast cancer[J].Invest New Drug,2005,23(5):391-409.
• [19]HARRELL M I,IRITANI B M,RUDDELL A.Tumor-induced sentinel lymph node lymphangiogene-sis and increased lymph flow precede melanoma me-tastasis[J].Am J Pathol,2007,170(2):774-786.
• [20]孙岚,张英鸽,杨留中.纳米活性炭在小鼠体内的分布、存留及淋巴靶向性[J].军事医学科学院院刊,2005,29(4):349-351.
• [21]张文超,张仑,王旭东,等.以纳米活性炭为载体的平阳霉素对口腔鳞状细胞癌淋巴化疗的实验研究[J].天津医科大学学报,2008,14(3):319-323.
• [22]董怡民,沓小容,姚崇舜,等.纳米活性炭对氟尿嘧啶的吸附和缓释作用的实验研究[J].中国医科大学学报,2004,33(3):205-211.
• [23]黄广建,陈忠清,刘懿,等.活性炭纳米粒对胃癌淋巴清扫的指导作用[J].中国现代医学杂志,2005,15(2):233-235.
• [24]谢萍,谢永美,宋鑫,等.亲水性接枝纳米炭的制备及其淋巴靶向特性的研究[J].华西药学杂志,2006,21(4):337-339.
• [25]梁寒,唐贺文,郝希山,等.活性炭吸附丝裂霉素C腹腔化疗的药代动力学研究[J].中华肿瘤杂志,2005,2(7):412-415.
• [26]陈浩,黄广建,倪泉兴,等.纳米活性碳作为药物载体在淋巴靶向治疗中的作用[J].复旦学报:医学版,2007,34(4):518-521.
• [27]董树荣,张孝彬,涂江平,等.新型纳米材料-纳米碳管[J].材料科学与工程,1998,16(2):19-23.
• [28]王雪.功能化碳纳米管及超支化聚合物的制备和在医药上的应用[D].上海:上海交通大学,2009.
• [29]YANG Dong,YANG Feng,HU Jian-hua,et al.Hy-drophilic multi-walled carbon nanotubes decoratedwith magnetite nanoparticles as lymphatic targeteddrug delivery vehicles[J].Chem Commun,2009,29:4447-4449.
• [30]谷怀民,杨思华,向良忠.光声成像及其在生物医学中的应用[J].生物化学与生物物理进展,2006,33(5):431-437.
• [31]PRAMANIK M,SONG K H,SWIERCZEWSKA M,et al.In vivo carbon nanotube-enhanced non-invasivephotoacoustic mapping of the sentinel lymph node[J].Phys Med Biol,2009,54(11):3291-3301.
• [32]YANG Feng,JIN Chen,YANG Dong.Magnetic func-tionalised carbon nanotubes as drug vehicles for canc-er lymph node metastasis treatment[J].Eur J Cancer,2011,47(12):1873-1882.