徐璐,李三鸣,刘婷,赵国斌
XU Lu 1; LI San-ming 1; LIU Ting 1; ZHAO Guo-bin 2 (1. School of Pharmacy;

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院
• 3:沈阳药科大学药学院
• 4:吉林省药品检验所 辽宁沈阳110016

摘要(Abstract)：

目的研究卡托普利渗透泵型控释片在家犬体内的药代动力学。方法以卡托普利普通片为对照 ,应用HPLC法测定血药浓度。结果卡托普利渗透泵型控释片和普通片的tmax分别为 5 5h和 1 5h ,t1/ 2 分别为 6 73h和 3 5 2h ,ρmax分别为 85 5 1和 172 5 3μg·L-1。相对生物利用度为(119 2 0± 2 3 2 0 ) %。结论渗透泵控释片血药浓度平稳 ,可较长时间保持有效血药浓度
Objective To study pharmacokinetics of dogs in vivo of captopril osmotic pump controlled release tablets.Method With Captopril common tablets as the reference,blood drug concentration was determined by HPLC.Results Main pharmacokinetic parameters are followed:t max of captopril osmotic pump controlled release tablets and reference tablets are 5.5 h and 1.5 h,t 1/2 are 6.73 h和 3.52 h,ρ max are 855.1 and 1 725.3 μg·L -1.Relative bioavailability is (119.20±23.20)%.Conclusion Plasma drug concentration of captopril osmotic pump controlled release tablets is balanced and effective plasma drug concentration is kept in longer time.

关键词(KeyWords)： 卡托普利;渗透泵控释片;高效液相色谱法;生物利用度;药代动力学
captopril; osmotic pump controlled release tablets; HPLC; bioavailability; pharmacokinetics

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 徐璐,李三鸣,刘婷,赵国斌
XU Lu 1; LI San-ming 1; LIU Ting 1; ZHAO Guo-bin 2 (1. School of Pharmacy;

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