许磊,吕帅,孙博航,高慧媛,吴立军
XU Lei,L Shuai,SUN Bo-hang,GAO Hui-yuan,WU Li-jun(School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院

摘要(Abstract)：

目的对辽细辛(Asarum heterotropidesFr Schmidt.var.mandshuricum(Maxim.)Kitag.)地上部分的化学成分进行研究。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和NMR波谱数据进行结构鉴定。结果分离得到6个化合物,分别鉴定为(10bS)8,9-dihydroxy-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one(1)、尼古丁酸(nicotinic acid,2)、5-羟甲基糠酸(5-hy-droxymethyl-furoic acid,3)、琥珀酸(succinic acid,4)、山奈酚(kaempferol,5)、山奈酚3-O--βD-吡喃葡萄糖苷(kaempferol-3-O--βD-glucopyranoside,6)。结论化合物1~3为首次从细辛属植物中分离得到,化合物5为首次从辽细辛中分离得到。
Objective To study the chemical constituents of aerial parts of Asarum heterotropides Fr Schmidt.var.mandshuricum(Maxim.)Kitag.Methods The compounds were isolated by chromatography on silica gel column and identified by the physiochemical properties and spectral analysis.Results Six compounds were obtained and identified as(10bS) 8,9-dihydroxy-1,5,6,10b-tetrahydro-2H-pyrroloisoquinolin-3-one(1),nicotinic acid(2),5-hydroxymethylfuroic acid(3),succinic acid(4),kaempferol(5),kaempferol-3-O-β-D-glucopyranoside(6).Conclusions Compounds 13 are firstly isolated from Asarum.Compound 5 is isolated from Asarum heterotropides Fr Schmidt.var.mandshuricum(Maxim.)Kitag.for the first time.

关键词(KeyWords)： 辽细辛;地上部分;化学成分;结构鉴定
Asarum heterotropides Fr Schmidt.var.mandshuricum(Maxim.)Kitag.;aerial part;chemical constituent;structure identification

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划子课题(2006BAI06A00)

作者(Author): 许磊,吕帅,孙博航,高慧媛,吴立军
XU Lei,L Shuai,SUN Bo-hang,GAO Hui-yuan,WU Li-jun(School of Traditional Chinese Materia Medica

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