梁大连,于亮,李宁,刘玉黔,郭琪,王芳
LIANG Da-lian,YU Liang,LI Ning,LIU Yu-qian,GUO Qi,WANG Fang

• 1:山东省药学科学院山东省化学药物重点实验室
• 2:沈阳药科大学中药学院

摘要(Abstract)：

目的研究过山蕨(Camptosorus sibiricus Rupr.)水提物的化学成分。方法通过正相硅胶、MCI树脂、Sephadex LH-20、制备薄层色谱和反相HPLC等多种色谱技术,对过山蕨水煎煮提取物的化学成分进行分离纯化,通过波谱数据分析,鉴定了化合物的结构。结果共分离得到9个化合物,分别鉴定为:苄醇-O-β-D-吡喃葡萄糖苷(1)、3,5-二甲氧基-4-羟基-苯甲酰基-O-β-D-吡喃葡萄糖酯(2)、4-羟基-3-甲氧苯基-O-β-D-吡喃葡萄糖苷(3)、3,5-二甲氧基-4-羟基苯基-O-β-D-吡喃葡萄糖苷(4)、4-(2-羟乙基)-2-甲氧苯基-O-β-D-吡喃葡萄糖苷(5)、银桦苷G(6)、2-(4-羟苯基)乙基-O-β-D-吡喃葡萄糖苷(7)、2-(3,4-二羟基苯基)乙基-O-β-D-吡喃葡萄糖苷(8)、2-羟基-5-(2-羟乙基)-苯基-O-β-D-吡喃葡萄糖苷(9)。结论化合物1-9均为从过山蕨属中首次分离得到。
Objective To investigate the chemical constituents of the water extract from Camptosorus sibiricus Rupr. Methods Compounds were isolated by a combination of various chromatographic techniques including silica gel column chromatography,sephadex LH-20 column chromatography and reversed-phase HPLC. Their structure was elucidated on the basis of their physicochemical properties and spectral data.Results Nine compounds were identified as benzyl alcohol-O-β-D-glucoside( 1),3,5-dimethoxy-4-hydroxybenzoylO-β-D-glucopyranosyl ester( 2),tachioside( 3),3,5-dimethoxy-4-hydroxyphenyl-O-β-Dglucopyranoside(4),4-( 2-hydroxyethyl)-2-methoxyphenyl-O-β-D-glucopyranoside( 5),g revilloside G( 6),2-( 4-hydroxyphenyl) ethyl-O-β-D-glucopyranoside( 7), 2-( 3, 4-dihydroxyphenyl) ethyl-O-β-Dglucopyranoside(8),and 2-hydroxy-5-( 2-hydroxyethyl)-phenyl-O-β-D-glucopyranoside( 9), respectively.Conclusions Compounds 1-9 are isolated from the Camptosorus for the first time.

关键词(KeyWords)： 过山蕨;过山蕨属;水提物;苯乙醇苷
Camptosorus sibiricus Rupr.;Camptosorus;water extract;phenylethanoid glycosides

Abstract:

Keywords:

基金项目(Foundation): 国家重大新药创制项目(2010ZX09401302-002-015);; 山东省重点研发计划项目(2016GSF202006)

作者(Author): 梁大连,于亮,李宁,刘玉黔,郭琪,王芳
LIANG Da-lian,YU Liang,LI Ning,LIU Yu-qian,GUO Qi,WANG Fang

DOI: 10.14066/j.cnki.cn21-1349/r.2017.07.002

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