小蓟化学成分的分离与鉴定Isolation and identification of chemical constituents from Cirsium setosum(Willd.) MB.
韩百翠,李宁,李铣
HAN Bai-cui,LI Ning,LI Xian(School of Traditional Chinese Materia Medica
摘要(Abstract)：
目的对传统中药小蓟的化学成分进行分离与鉴定,为进一步开发利用小蓟提供科学依据。方法采用反复硅胶柱色谱法进行分离纯化,通过理化常数测定和波谱分析鉴定其化学结构。结果从小蓟提取物的氯仿层和乙酸乙酯层中分离得到9个化合物,即苜蓿素(tricin,1)、蒙花苷(linarin,2)、咖啡酸(caffeic acid,3)、香豆酸(courmaric acid,4)、丁二酸(succinic acid,5)、芹菜素(apigenin,6)、苜蓿素-7-O-β-D-葡萄糖(tricin-7-O-β-D-glucopyranoside,7)、β-谷甾醇(β-sitosterol,8)、β-胡萝卜苷(β-daucosterol,9)。结论化合物5、7为首次从蓟属植物中分离得到,化合物1、4为首次从小蓟中分离得到。
Objective To isolate and identify the chemical constituents from Cirsium setosum(Willd.)MB.Methods The compounds were isolated by chromatography on silica gel column and identified on the basis of physico-chemical constants and spectral analysis.Results Nine compounds were isolated and their structures were identified as tricin(1),linarin(2),caffeic acid(3),courmaric acid(4),succinic acid(5),apigenin(6),tricin-7-O-β-D-glucopyranoside(7),β-sitosterol(8)and β-daucosterol(9),respectively.Conclusions Compounds 5 and 7 are reported from this genus for the first time,compounds 1 and 4 are isolated from this plant firstly.
关键词(KeyWords)：
刺儿菜;化学成分;分离;结构鉴定
Cirsium setosum(Willd.)MB.;chemical constituent;isolation;structure identification
基金项目(Foundation):
作者(Author):
韩百翠,李宁,李铣
HAN Bai-cui,LI Ning,LI Xian(School of Traditional Chinese Materia Medica
参考文献(References)：
- [1]李清华.小蓟止血成分的研究[J].中草药,1982,13(9):9-12.
- [2]顾玉诚,屠呦呦.小蓟化学成分研究[J].中国中药杂志,1992,17(9):547-548.
- [3]陈泉,吴立军,王军,等.中药淡竹叶的化学成分研究[J].沈阳药科大学学报,2002,19(1):23-24.
- [4]潘珂,尹永芹,孔令义.小蓟化学成分的研究[J].中国现代中药,2006,8(4):7-9.
- [5]李宁,李铣,杨世林,等.过山蕨中有机酸类化学成分研究[J].沈阳药科大学学报,2006,23(7):427-429.
- [6]张戈,郭美丽,李颖,等.红花化学成分研究(Ⅱ)[J].第二军医大学学报,2005,26(2):220-221.
- [7]黄洪波,包文芳,杨芳芳,等.灯盏花的化学成分研究[J].沈阳药科大学学报,2001,18(4):266-267.