紫杉醇固体脂质纳米粒大鼠体内药动学Pharmacokinetics of solid lipid nanoparticles containing paclitaxel in rats
孙铭,韩静,张多婷,张玥,杨静,李智
SUN Ming,HAN Jing,ZHANG Duo-ting,ZHANG Yue,YANG Jing,LI Zhi(School of Pharmaceutical Engineering
摘要(Abstract)：
目的研究紫杉醇固体脂质纳米粒在大鼠体内的药动学。方法10只健康大鼠,雌雄各半,分为2组,分别口服给药紫杉醇固体脂质纳米粒和紫杉醇乳剂30 mg.kg-1,在设计的时间点从颈静脉取血,采用RP-HPLC测定紫杉醇在全血中的药物浓度,药动学参数用3P97软件进行处理。结果大鼠口服给药后,紫杉醇固体脂质纳米粒和乳剂的tm ax分别为3.133 h和1.627 h,MRT分别为10.362 h和3.297 h,mρax分别为1.512 2 mg.L-1和0.718 9 mg.L-1。结论固体脂质纳米粒能够显著改善大鼠体内紫杉醇的药动学行为,有利于其更好地发挥抗肿瘤作用。
Objective To establish a method to study the pharmacokinetics of paclitaxel in solid lipid nanoparticles(PSLN)in rats.Methods Ten rats,half the male and half the female,were divided into two groups randomly.Paclitaxel of 30 mg·kg-1 was administered to animals and the plasma concentration of paclitaxel in blood were simultaneously determined by RP-HPLC.The pharmacokinetic parameters of solid lipid nanoparticle and emulsion containing paclitaxel were calculated by 3P97.Results After the administration of two formulations,the MRTs of paclitaxel in solid lipid nanoparticles and emulsion were 10.362 h and 3.297 h,respectively,the tmax were 3.133 h and 1.627 h,while the ρmax were 1.512 2 mg·L-1and 0.718 9 mg·L-1,respectively.Conclusions Pharmacokinetic behavior of paclitaxel is significantly improved by solid lipid nanoparticles.
关键词(KeyWords)：
紫杉醇;反相高效液相色谱法;固体脂质纳米粒;药动学
paclitaxel;RP-HPLC;solid lipid nanoparticle;pharmacokinetics
基金项目(Foundation):
作者(Author):
孙铭,韩静,张多婷,张玥,杨静,李智
SUN Ming,HAN Jing,ZHANG Duo-ting,ZHANG Yue,YANG Jing,LI Zhi(School of Pharmaceutical Engineering
DOI: 10.14066/j.cnki.cn21-1349/r.2010.03.016
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