吴雪英,刘明,吴英良,郭远强,李玉山
WU Xue-ying1,LIU Ming1,WU Ying-liang2,GUO Yuan-qiang3,LI Yu-shan1(1.School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院
• 2:沈阳药科大学生命科学与生物制药学院
• 3:南开大学药学院

摘要(Abstract)：

目的对远志根的化学成分进行研究。方法采用反复硅胶柱色谱、Sephadex LH-20柱色谱和半微量制备高效液相色谱分离纯化,根据ESI-MS、1H-NMR和13C-NMR等谱学数据进行结构鉴定。结果从远志根的乙醇提取物中分离得到11个单体化合物,分别鉴定为蔗糖酯类化合物西伯利亚远志糖A5(sibiricose A5,1)、tenuifolioside A(α-D-glucopyranoside,3-O-[(2Z)-3-(4-hydroxy-3-me-thoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,2)、tenuifolioside B(α-D-glucopyranoside,3-O-[(2E)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,3)、tenuifolioside C(α-D-glucopyranoside,3-O-[(2Z)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofurano-syl,4)、西伯利亚远志糖A6(sibiricose A6,5)、球腺糖A(glomeratose A,6);呫吨酮类化合物西伯利亚远志呫吨酮B(sibiricaxanthone B,7)、远志呫吨酮Ⅺ(polygalaxanthoneⅪ,8)、1,2,3,7-四甲氧基呫吨酮(1,2,3,7-tetramethoxyxanthone,9)和远志酮Ⅱ(onjixanthoneⅡ,10);远志醇(polygitol,11)。结论化合物2~4为首次发现的新化合物。
Objective To study the constituents of the extract from the root of Polygala tenuifolia Willd.Methods The chemical constituents were isolated by silica,Sephadex LH-20 gel column chromatography and HPLC.Chemical characters and spectroscopic analysis were employed for the structural identification.Results Eleven compounds were obtained and their structures were identified as sibiricose A5(1),tenuifolioside A(α-D-glucopyranoside,3-O-[(2Z)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,2),tenuifolioside B(α-D-glucopyranoside,3-O-[(2E)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,3),tenuifolioside C(α-D-glucopyranoside,3-O-[(2Z)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-fructofuranosyl,4),sibiricose A6(5),glomeratose A(6),sibiricaxanthone B(7),polygalaxanthone Ⅺ(8),1,2,3,7-tetramethoxyxanthone(9),onjixanthoneⅡ(10),and polygitol(11).Conclusions Compounds 24,named tenuifolioside A-C respectively,are new sucrose esters which have not been reported before.

关键词(KeyWords)： 细叶远志;化学成分;蔗糖酯类;呫吨酮类;结构鉴定
Polygala tenuifolia;chemical constituent;sucrose ester;xanthone;structure identification

Abstract:

Keywords:

基金项目(Foundation): 辽宁省自然科学基金资助项目(200620576)

作者(Author): 吴雪英,刘明,吴英良,郭远强,李玉山
WU Xue-ying1,LIU Ming1,WU Ying-liang2,GUO Yuan-qiang3,LI Yu-shan1(1.School of Traditional Chinese Materia Medica

DOI: 10.14066/j.cnki.cn21-1349/r.2010.10.003

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