韩颖,金艺淑,于建婷,李军,李玉山
HAN Ying1,JIN Yi-shu2,YU Jian-ting1,LI Jun1,LI Yu-shan1(1.School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院
• 2:沈阳医学院沈洲医院

摘要(Abstract)：

目的对高山红景天药材的化学成分进行研究。方法采用反复硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱和半微量制备高效液相色谱分离纯化,根据ESI-MS、1H-NMR和13C-NMR等谱学数据进行结构鉴定。结果从高山红景天根和根茎的乙醇提取物中分离得到8个单体化合物,分别鉴定为黄酮类化合物herbacetin 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside(1)、三叶豆苷(trifolin,2)、草质素苷(rhodionin,3)、山奈酚(kaempferol,4)、山奈酚7-O-α-L-鼠李糖苷(kaempferol7-O-α-L-rhamnopyranoside,5)、小麦黄素(tricin,6)和大花红景天素(rhodiolinin,7);另外还得到2(3H)-苯并噻唑硫酮(2(3H)-benzothiazolethione,8)。结论化合物1为新化合物,化合物2和8为首次从景天科植物中分离得到。
Objective To study chemical constituents of root and rhizome of Rhodiola sachalinensis A.Bor. Methods The chemical constituents were isolated by silica,Sephadex LH-20,ODS column chromatography and HPLC.Chemical characters and spectroscopic analysis were employed for the structural identification. Results Eight compounds were obtained and their structures were identified as:herbacetin 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside(1),trifolin(2),rhodionin(3),kaempferol(4),kaempferol 7-O-α-L-rhamnopyranoside(5),tricin(6),rhodiolinin(7)and 2(3H)-benzothiazolethione(8). Conclusions Herbacetin 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside(1)is a new flavonol glucoside which has not been reported before.Compounds 2 and 8 are isolated from family Crassulaceae for the first time.

关键词(KeyWords)： 高山红景天;黄酮;2(3H)-苯并噻唑硫酮;结构鉴定
Rhodiola sachalinensis A.Bor.;flavone;2(3H)-benzothiazolethione;structure identification

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 韩颖,金艺淑,于建婷,李军,李玉山
HAN Ying1,JIN Yi-shu2,YU Jian-ting1,LI Jun1,LI Yu-shan1(1.School of Traditional Chinese Materia Medica

DOI: 10.14066/j.cnki.cn21-1349/r.2011.02.015

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