李明雪,吴灿荣,郑梦竹,张鹏,王亚丽,刘洋,项珂,徐阳,王琪琪,杨月影,陈丽霞,李华
LI Mingxue,WU Canrong,ZHENG Mengzhu,ZHANG Peng,WANG Yali,LIU Yang,XIANG Ke,XU Yang,WANG Qiqi,YANG Yueying,CHEN Lixia,LI Hua

• 1:沈阳药科大学无涯创新学院
• 2:华中科技大学同济医学院药学院

摘要(Abstract)：

目的探讨和阐述冠状病毒(coronaviruses,CoVs)的分类、来源、致病性、蛋白靶点结构、疫苗和治疗药物的研究进展。方法查阅关于冠状病毒相关研究的文献159篇,对冠状病毒的分类、来源、致病性、药物作用靶点结构、对应疫苗和治疗药物的研发进行总结和分析。结果冠状病毒是一类严重危害人类和动物健康的病原微生物,属于具有大量天然宿主的一类RNA病毒。该病毒极易发生基因重组和变异,具有遗传多样性,迄今为止,已不断有新亚型或新的冠状病毒出现。冠状病毒上的S蛋白、PLpro和3CLpro是药物开发的良好靶点,总结了基于以上靶标发现的潜在药物。结论在过去的几十年中,由冠状病毒引起的疾病对全球公共卫生造成了巨大威胁,例如,严重的急性呼吸综合症病毒(SARS)、中东呼吸综合症病毒(MERS)以及最近出现的新型冠状病毒(SARS-CoV-2)等。然而,到目前为止并没有针对SARS-CoV、MERS-CoV、SARS-CoV-2和其他HCoV感染的特异性疗法。因此,仍需对冠状病毒进行全面深入的研究。
Objective To discussandexpound the classification,origin,pathogenicity,protein target structure,vaccines and therapeutic drugs for coronavirus(CoVs).Methods After reading 159 literatures about coronavirus,we summarized and analyzed the classification,origin,pathogenicity,target structure of drug action,corresponding vaccines and therapeutic drugs development for CoVs.Results CoVs is a type of pathogenic microorganism that seriously endangers human and animal health,which belongs to a RNA virus with a large amount of natural hosts.The virus is prone to gene recombination and mutation,and has genetic diversity.So far,new subtypes or coronaviruses are emerging continuously.CoVsS protein,PLpro and 3 CLpro are good targets for drug development.We summarized the drugs found based on the above targets.Conclusion In the past few decades,diseases caused by coronavirus have posed a great threat to global public health,for example,severe acute respiratory syndrome virus(SARS),Middle East respiratory syndrome virus(MERS) and the recently emerging new coronavirus(SARS-CoV-2).However,there is no specific therapy for SARS-CoV,MERS-CoV,SARS-CoV-2 and other HCoV infections so far.Therefore,comprehensive and in-depth research on coronavirus is still a need.

关键词(KeyWords)： 冠状病毒;SARS-CoV;MERS-CoV;SARS-CoV-2;基于结构药物发现
coronavirus;SARS-CoV;MERS-CoV;SARS-CoV-2;structure-based drug discovery

Abstract:

Keywords:

基金项目(Foundation): 国家“十三五”科技重大专项(2019ZX09721001-004-007)资助;; 兴辽英才计划青年拔尖人才项目(XLYC1807182)

作者(Author): 李明雪,吴灿荣,郑梦竹,张鹏,王亚丽,刘洋,项珂,徐阳,王琪琪,杨月影,陈丽霞,李华
LI Mingxue,WU Canrong,ZHENG Mengzhu,ZHANG Peng,WANG Yali,LIU Yang,XIANG Ke,XU Yang,WANG Qiqi,YANG Yueying,CHEN Lixia,LI Hua

DOI: 10.14066/j.cnki.cn21-1349/r.2020.05.001

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