黄梅,吴春福
HUANG Mei; WU Chun fu (School of Pharmacy;

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院 辽宁沈阳110016
• 3:辽宁沈阳110016

摘要(Abstract)：

目的综述抗环血酸在中枢神经系统中的功能以及神经递质对其的调节作用。方法查阅近年来国内外公开发表的有关研究论文 ,按功能和调节作用分类汇总。结果研究成果表明 ,抗环血酸在中枢不仅表现为抗氧化作用 ,还对神经递质、酶类及神经肽等物质起到调节作用 ,并且共浓度、释放以及功能受到中枢神经递质的调节。结论抗环血酸在中枢神经系统中的功能复发杂而重要 ,并受到多种节作用
Objective This review focused on the function of ascorbic acid and regulative effects of the nervous transmitters on it in the brain.Method Study papers reported in Journals had been consulted,and classified by function and regulative effects.Results Studies show that ascorbic acid not only plays a role as an antioxidant,but also has regulative effects on the nervous transmitters enzymes and neuropeptides,and transmitters can regulate the level,release and function of ascorbic acid.Conclusions Ascorbic acid acts as a complex and important compound,and is regulated by some nervous transmitters in brain.

关键词(KeyWords)： 抗坏血酸;中枢神经系统;功能;调节
ascorbic acid; central nervous system; function; regulation

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 黄梅,吴春福
HUANG Mei; WU Chun fu (School of Pharmacy;

参考文献(References)：

• [1]VatasseryGT .InvivooxidationofVcandVE ,cholesterol,andthiolsinratbrainsynaptosomes[J].Lipids,1995,30:1007-1013.
• [2]TanS ,FenZ ,VanceGN ,etal.Increasedinjuryfol lowingintermittentfetalhypoxia reoxygenationisas sociatedwithincreasedfreeradicalproductioninfetalrabbitbrain[J].JNeuropathExperNeurol,1999,58(9):972-981.
• [3]RiceME .Useofascorbateinthepreparationandmaintenceofbrainslices[J].Methods,1999,18(2):144-149.
• [4]KiyatkinEA ,GeorgeRV .Ascorbatemodulatesglutamate inducedexcitationsofstriatalneurons[J].BrainRes,1998,812(1,2):14-22.
• [5]ReiserM ,LorenzS ,GerburgK ,etal.InteractionofnitricoxidedonorsandascorbicacidonD
• [3H]aspar tateeffluxfromratstriatalslices[J].NeurochemRes,1999,24(1):61-67.
• [6]MieleM ,BoutelleMG ,FillenzM .Thephysiologi cally inducedreleaseofascorbateinratbrainisdepen dentonimpulsetraffic,calciuminfluxandglutamateuptake[J].Neuroscience,1994,62:87-91.
• [7]MajewskaMB ,BellJA ,LondonED .RegulationoftheNMDAreceptorbyredoxphenomena,inhibitoryroleofascorbate[J].BrainRes,1990,537:328-332.
• [8]MartaM ,MariaAA ,CarlosMGA .Ascorbicacidan tagonizesethanol inducedlocomotoractivityintheopen field[J].PharmacolBiochemBehav,1999,62(2):361-366.
• [9]StamfordJA ,IsaacD ,HicksCA ,etal.Ascorbicacidisneuroprotectiveagainstglobalischemiainstriatumbutnothippocampus:histologicalandvoltammetricdata[J].BrainRes,1999,835(2):229-240.
• [10]SogawaCA ,IkukoM ,NorioS ,etal.Antioxidantsprotectagainstdopamine inducedmetallothioneinⅢ(GIF)mRNAexpressioninmouseglialcellline(VR 2g)[J].BrainRes,2000,853(2):310-316.
• [11]JiangXR ,MonikaZW ,GlennD .Tryptamine4,5 dione,aputativeendotoxicmetaboliteofthesuperox ide mediatedoxidationofserotonin,isamitochondrialtoxin:possibleimpliationsinneurodegenerativebraindisorders[J].ChemResToxicol,1999,12(5):429-436.
• [12]YousefMI,ElDemerdashFM ,ElAgamyEI.EffectofascorbicacidonsomebiochemicalparametersofrabbitsaffectedbyaflatoxinB1[J].EnvironNutrIn teract,1999,3(3):141-153.
• [13]BijurGN ,BriggsB ,HitchcockCL ,etal.Ascorbicacid dehydroascorbateinducescellcyclearrestatG2/MDNAdamagecheckpointduringoxidativestress[J].EnvironMolMutagen,1999,33(2):144-152.
• [14]PodmoreID ,GriffithsHR ,HerbertKE ,etal.Vita mineCexhibitspro oxidantproperties[J].Nature,1998,392:559.
• [15]JoshuaMG ,GeorgeRV .Modulatoryeffectsofascor bate,aloneorwithhaloperidol,onalever releasecon ditionedavoidanceresponsetask[J].PharmacolBiochemBehav,1999,63(1):125-129.
• [16]MorelP ,BernardF ,GuyleneP ,etal.Inhibitoryef fectsofascorbicacidondopamineuptakebyratstri atalsynaptosomes:relationshiptolipid peroxidationandoxidationofproteinsulfhydrylgroups[J].Neu rosciRes,1998,32(2):171-179.
• [17]ElliotL ,AlanG .Releaseoftheantioxidantsascorbateanduratefromanitrergically innervatedsmoothmus cle[J].BrJPharmacol,1997,122:1746-1752.
• [18]MargaretER .Ascorbateregulationanditsneuropro tectiveroleinthebrain[J].TrendsNeurosci,2000,23:209-216.
• [19]DunlapCE ,LeslieFM .Effectofascorbateonthetoxicityofmorphineinmice[J].Neuropharmaco logy,1985,24:797804.
• [20]SharadaK ,WenHY ,AnnaW ,etal.Ascorbicacidactsasinhibitorytransmitterinthehypothalamustoinhibitstimulatedluteinizinghormone releasing[J].ProcNatlAcadSciUSA ,1999,97:1891-1896.
• [21]WilsonJX ,PetersCE ,SitarSM ,etal.Glutamatestimulatesascorbatetransportbyastrocytes[J].BrainRes,2000,858(1):61-66.
• [22]CammackJ,GhasemzadehB ,AdamsRN .Thephar macologicalprofileofglutamate evokedascorbicacideffluxmeasuredbyinvivoelectrochemistry[J].BrainRes,1991,565:17-22.
• [23]LiuJ,WuCF ,LiuW ,etal.Involvementofthecor ticostriatalglutamatergicpathwayinethanol inducedascorbicacidreleaseintheratstriatum[J].AddictBiol,1999,4:273-281.
• [24]PierceCR ,RebecGV .StimulationofbothD1andD2dopaminereceptorsincreasesbehavioralactivationandascorbatereleaseintheneostriatumoffreelymovingrats[J].EurJPharmacol,1990,191:295-302.
• [25]LiuW ,WuCF ,HuangM ,etal.OppositeeffectsofsulpirideandSCH 23390onethanol inducedstriatalascorbicacidreleaseinintactand6 hydroxydopaminelesionedrats[J].BrainRes,2000,869:31-38.
• [26]RodMS ,KathyrneM ,DougK ,etal.Theeffectsofhaloperidol,scopolamine,andMK 801onam phetamine inducedincreasesinascorbicacidanduridacidasdeterminedbyvoltammeryinvivo[J].Phar macolBiochemBehav,1994,48(1):161-168.
• [27]WuCF ,LiuW ,LiuJ,etal.dlFenfluraminein hibitsethanol inducedascorbicacidreleaseinratstria tumstudiedbymicrodialysis[J].AddictBiol,1998,3:295-308.
• [28]WuCF ,LiuJ,SilvanaC ,etal.5HT1Areceptorsmediateinhibitionofethanol inducedascorbicacidre leaseinratstriatumstudiedbymicrodialysis[J].NeurosciLett,1998,250:95-98.
• [29]WuCF ,LiuJ,ConsoloS ,etal.Failureof5HT3receptorsinregulationofethanol inducedascorbicacidreleaseinratstriatum[J].AddictBiol,2001,6:25-34.