李墨,赵秀丽,陈大为,杨云云
LI Mo,ZHAO Xiu-li,CHEN Da-wei,YANG Yun-yun(School of Pharmacy

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院
• 3:沈阳药科大学药学院
• 4:沈阳药科大学药学院 辽宁沈阳110016

摘要(Abstract)：

目的对注射用葫芦素B自微乳化药物传递系统进行处方优化。方法在注射级辅料中筛选油相、乳化剂和助乳化剂,根据空白假三元相图和粒径分析进一步优化处方。结果最佳处方组成为m(油酸乙酯)∶m(Cremophor RH)∶m(乙醇)=30∶55∶15,其中药物含量的质量分数为1%。结论可按照最佳处方组成制备注射用葫芦素B自微乳化药物传递系统。
Objective To search for the optimum formulation for the self-microemulsifying drug delivery system of cucurbitacin B.Methods The oils,emulsifiers and co-emulsifiers from adjuncts for injection were screened,the pseudo-ternary phase diagram of blank self-microemulsifying drug delivery system was drawn and particle size was analyzed to determine the optimum formulation.Results The constitution of optimum formulation was as follows:m(ethyl oleate):m(Cremophor RH):m(ethanol) =30∶55∶15.Conclusions Self-microemulsifying drug delivery system of cucurbitacin B can be prepared according to the optimum formulation.

关键词(KeyWords)： 葫芦素B;自微乳化药物传递系统;处方优化;假三元相图
cucurbitacin B;self-microemulsifying drug delivery system(SMEDDS);formulation optimization;pseudo-ternary phase diagram

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李墨,赵秀丽,陈大为,杨云云
LI Mo,ZHAO Xiu-li,CHEN Da-wei,YANG Yun-yun(School of Pharmacy

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