沈阳药科大学学报

2010, v.27;No.178(11) 853-856+875

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葫芦素E溶解度、正辛醇-水及脂质体-水分配系数测定
Solubility,n-octanol-water and liposome-water partition coefficients of cucurbitacin E

刘克非,李晓峰,张雅昕,王范,王岩,邓意辉
LIU Ke-fei,LI Xiao-feng,ZHANG Ya-xin,WANG Fan,WANG Yan,DENG Yi-hui(School of Pharmacy

摘要(Abstract):

目的测定葫芦素E溶解度、正辛醇-水分配系数及脂质体-水分配系数。方法分别采用平衡法、经典摇瓶法及平衡透析法测定葫芦素E溶解度、正辛醇-水分配系数及脂质体-水分配系数。结果葫芦素E在水中溶解度为0.155 mg.L-1,在乙醇、叔丁醇中有潜溶现象;正辛醇-水分配系数为(2.088±0.054);脂质体-水分配系数为0.003~1.819。结论葫芦素E为水不溶性药物;正辛醇-水分配系数及脂质体-水分配系数均中等偏低。
Objective To determine the solubility of cucurbitacin E and its partition coefficients for n-octanol-water and liposome-water solution systems.Methods The solubility,partition coefficient for n-octanol-water and liposome-water were measured by equilibrium method,shaking flask and equilibrium dialysis method,respectively.Results The solubility of cucurbitacin E in water was 0.155 mg·L-1,it was cosolvent in ethanol and tertiary butyl alcohol,the partition coefficients for n-octanol-water and liposome-water were(2.088±0.054)and(0.003-1.819),respectively.Conclusions Cucurbitacin E is insoluble in water,its partition coefficients for n-octanol-water and liposome-water are moderate.

关键词(KeyWords): 葫芦素E;溶解度;潜溶;正辛醇-水分配系数;脂质体-水分配系数
cucurbitacin E;solubility;cosolvency;n-octanol-water partition coefficient;liposome-water partition coefficient

Abstract:

Keywords:

基金项目(Foundation): 国家973自然科学基金资助项目(2009CB930300);; 国家科技部重大新药创制项目(2008ZX09401-004)

作者(Author): 刘克非,李晓峰,张雅昕,王范,王岩,邓意辉
LIU Ke-fei,LI Xiao-feng,ZHANG Ya-xin,WANG Fan,WANG Yan,DENG Yi-hui(School of Pharmacy

DOI: 10.14066/j.cnki.cn21-1349/r.2010.11.014

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