周蓓,朱晓明
ZHOU Bei 1; ZHU Xiao-ming 2 (1. School of Traditional Chinese Materia Medica;

• 1:沈阳药科大学中药学院
• 2:中国人民解放军第202医院 辽宁沈阳110016
• 3:辽宁沈阳110003

摘要(Abstract)：

目的对化浊解毒汤治疗慢性肾功能衰竭大鼠的作用机理进行探讨。方法用腺嘌呤诱发肾衰模型 ,再用化浊解毒汤灌胃治疗 4周 ,以包醛氧化淀粉作阳性对照药。结果化浊解毒汤能降低大鼠血清肌酐 (Scr)、尿素氮 (BUN)水平 ,改善肾功能 ,并且具有抗氧化作用 (P <0 0 5 )。肾小管及间质内结晶沉积物明显减少 ,部分肾小管形态结构接近正常 ,光镜下肾脏病理明显改善。结论化浊解毒汤能明显改善肾功能 ,抑制慢性肾衰的发展
Objective To study the mechanism of the Huazhuo Jiedu Decoction (HZJDD) used in the experimental rat models of the chronic renal failure(CRF) was studied in this paper. Methods The model of CRF was induced by adenine. Then one group was treated with the HZJDD by the gastrogavage for 4 weeks. coated aldehyde oxystarch was used as a control drug. Results The HZJDD could not only reduce the levels of blood urea nitrogen(BUN),serum creatinine(Scr),improve the renal function, but also have the function of antioxidation(P<0.05),it also reduced the crystals in renal tubules and interrenal tissues. The constitution of some renal tubules was close to a normalone. The pathological lesions improved significantly after treatment under the light-microscopic examination. Conclusions The HZJDD could improve the renal function significantly and inhibit the progression of CRF.

关键词(KeyWords)： 化浊解毒汤;慢性肾功能衰竭;腺嘌呤;包醛氧化淀粉
Huazhuo Jiedu Decoction; chronic renal failure; adenine; coated aldehyde oxystarch

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 周蓓,朱晓明
ZHOU Bei 1; ZHU Xiao-ming 2 (1. School of Traditional Chinese Materia Medica;

参考文献(References)：

• [1]郑平东,朱燕俐,丁名城,等.用腺嘌呤制作慢性肾功能衰竭动物模型[J].中华肾脏病杂志,1989,5(6):342-344.
• [2]李丛.大黄治疗慢性肾功能衰竭研究进展[J].江西中医学院学报,2000,12(2):84-86.
• [3]宓鹤鸣,郭澄,宋洪涛,等.三种菟丝子补肾壮阳作用的比较[J].中草药,1991,6(1):547-550.
• [4]宋菊敏,毛良,施建玲,等.糖尿宁对NIDDM大鼠的降糖,降脂及抗氧化作用[J].中成药,1993,15(4):25-26.