沈阳药科大学学报

2001, (01) 1-4

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HPMC、十八醇混合骨架片的研究
Studies on HPMC octadecanol mixed matrice

林晓,马汝敏,严青英,姚崇舜,陈济民
LIN Xiao; MA Ru min; YAN Qing ying; YAO Chong shun; CHEN Ji min (Department of Pharmacy;

摘要(Abstract):

以盐酸氢吗啡酮为模型药物 ,研究了羟丙基甲基纤维素 (HPMC)和十八醇混合使用时各自用量对骨架片释放的影响 ,并将这种影响与它们分别单独作为骨架材料时的情况作了比较。结果表明混合使用时这两种骨架材料用量对骨架片不同时间段释放的影响与它们单独使用时不同。而且混合使用后HPMC用量对骨架片释放的影响较它单独使用时要大 ,而十八醇用量对骨架片释放的影响则大大减小
The effects of the amount of hydroxypropylmethyl cellulose(HPMC)and octadecanol on the releases of hydromorphone hydrochloride matrix tablet were investigated,when these two excipient were used together or respectively.The results showed that there were some differences for the amount of these two materials on the release of matrix tablets in different periods between they were used alone or combined.HPMC content has more influence on drug release than it was used alone.However,the influences of the amount of octadecanol on drug release become much less when it was used with HPMC.

关键词(KeyWords): MPMC;十八醇;混合骨架片;盐酸氢吗啡酮
HPMC; octadecanol; mixed matrice; hydromorphone hydrochloride

Abstract:

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作者(Authors): 林晓,马汝敏,严青英,姚崇舜,陈济民
LIN Xiao; MA Ru min; YAN Qing ying; YAO Chong shun; CHEN Ji min (Department of Pharmacy;

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