张丹,丁萌,赵余庆
ZHANG Dan,DING Meng,ZHAO Yu-qing

• 1:沈阳药科大学中药学院
• 2:沈阳药科大学基于靶点的药物设计与研究教育部重点实验室

摘要(Abstract)：

目的应用水果中的有机酸代替强酸、强碱和酶等催化剂,转化制备活性人参皂苷,寻找绿色环保型制备工艺。方法对国内外约近10年的研究报道进行查阅整理和归纳。结果总结和评价了水果中的柠檬酸,苹果酸,葡萄酸等7种有机酸对活性人参皂苷的转化作用及应用特点。结论应用水果中的有机酸转化制备活性人参皂苷,可以避免无机酸碱在转化过程中所致的环境污染、转化效率低、酶转化成本高等问题,是一条具有较高价值的绿色制备路线。
Objective To utilize organic acids instead of strong acids,such as strong alkali and enzyme catalysts to transform and prepare active ginsenosides with an environment friendly preparation technology.Methods The relevant literatures reported in recent ten years were reviewed. Results The effects and characteristics of seven kinds of organic acids such as ascitric acid and malic acid were evaluated and summarized in terms of activating ginsenosides. Conclusions The use of environmental polluting inorganic acids can be taken place by fruity organic acids to activate ginsenosides. Meanwhile, the low activation efficiency and high price of enzymatic conversion process can be avoided. It is the green chemical preparation route with high application value,which has the advantages of high yield, low cost,simple operation and so on.

关键词(KeyWords)： 人参皂苷;水果中的有机酸;制备工艺
ginsenoside;fruity organic acid;preparation technology

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81273389)

作者(Author): 张丹,丁萌,赵余庆
ZHANG Dan,DING Meng,ZHAO Yu-qing

DOI: 10.14066/j.cnki.cn21-1349/r.2017.07.013

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