李娟,李显林,胡铁军,雷江
LI Juan1,LI Xian-lin1,HU Tie-jun2,LEI Jiang3(1.Shenyang No.1 Pharmaceutical Factory

• 1:沈阳第一制药厂
• 2:东北制药总厂
• 3:沈阳中海生物技术开发有限公司

摘要(Abstract)：

目的制备R-(+)-硫代四氢呋喃-2-甲酸。方法以四氢呋喃-2-甲酸为原料,经拆分、氯代、取代3步反应得到R-(+)-硫代四氢呋喃-2-甲酸。结果反应总收率为29%,产物结构经1H-NMR和MS确证。结论通过实验摸索了一条制备光学纯度的R-(+)-硫代四氢呋喃-2-甲酸的路线,该方法简单、易于操作。
Objective To prepare R-(+)-thiotetrahydrofuran-2-carboxylic acid.Methods R-(+)-thiotetrahydrofuran-2-carboxylic acid was synthesized from tetrahydrofuran-2-carboxylic acid via three steps:resolution,chlorination and displacement.Results The total yield was 29% and the structure of desired compound was confirmed by 1H-NMR and MS.Conclusions The new route for synthesis of R-(+)-thiotetrahydrofuran-2-carboxylic acid is developed,and the process is easy to operate.

关键词(KeyWords)： R-(+)-硫代四氢呋喃-2-甲酸;四氢呋喃-2-甲酸;合成
R-(+)-thiotetrahydrofuran-2carboxylic acid;tetrahydrofuran-2-carboxylic acid;synthesis

Abstract:

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基金项目(Foundation):

作者(Author): 李娟,李显林,胡铁军,雷江
LI Juan1,LI Xian-lin1,HU Tie-jun2,LEI Jiang3(1.Shenyang No.1 Pharmaceutical Factory

参考文献(References)：

• [1]PATTON S.Thiofuroic acid[J].J Am Chem Soc,1949,71:3571-3572.
• [2]MAAJI I,HIROMITSU I,TAKASHI N,et al.Processfor preparing optically active tetrahydro-2-furoic acid:US,4985575[P].1991-01-15.