细胞色素C在小鼠肝损伤及缺氧模型中的作用Effects of cytochrome C on perfused mice hepatic injury induced by CCl_4 and experimental models of mice′ hypoxia
陈安树,王敏伟,徐俊玖,甘乐凌
CHEN An shu; WANG Min wei; XU Jun jiu; GAN Le ling (School of Pharmacy;
摘要(Abstract)：
目的考虑研究细胞色素C对小鼠肝损伤及缺氧模型的作用。方法以CCl4 诱发的小鼠急性肝损伤模型 ,以及常压耐缺氧实验、氰化钾化学性缺氧实验、小鼠断头张口喘息时间、尾静脉注射空气引起心脑缺氧实验 4种耐缺氧实验模型研究细胞色素C的作用。结果细胞色素C在上述各模型中均无显著的药理学作用。结论细胞色素C对小鼠的肝损伤及缺氧模型无保护作用。
Objective To study the effect of cytochrome C on mice′ hepatic injury and hypoxia.Methods Mice′ hepatic injury induced by CCl 4 and four experimental models of mice′ hypoxia:mice′ hypoxia model under the normal pressure,chemical hypoxia model induced by KCN,mice′ decapitation model,the hypoxia model induced by injection air in tail vein was employed.Result The results showed that cytochrome C had no pharmacological effect on all of the above models.Conclusion Cytochrome C and no protection effect on mice′ hepatic injury and experimental hypoxia models of mice.
关键词(KeyWords)：
细胞色素C;小鼠;肝损伤;缺氧模型
cytochrome C; mice; hepatic injury; hypoxia model
基金项目(Foundation):
作者(Authors):
陈安树,王敏伟,徐俊玖,甘乐凌
CHEN An shu; WANG Min wei; XU Jun jiu; GAN Le ling (School of Pharmacy;
参考文献(References)：
- [1]汤新之.临床生物化学[M ].天津:天津科学技术出版社,1999.773-774.
- [2]日本医药情报组.日本医药品集[M].日本东京:日本药业时报社,1988.665-666.
- [3]李仪奎.中药药理实验方法学[M].上海:上海科学技术出版社,1991.458-459.
- [4]徐叔云.药理实验方法学[M ].北京:人民卫生出版社,1991.948.
- [5]黄矛.小鼠尾静脉注射空气的简易心脑缺氧模型[J].中国药理学与毒理学杂志,1988,5(2):141-142.
- [6]任邦哲.生物化学与临床医学[M].长沙:湖南科学技术出版社,1993.127-128.
- [7]徐晓丽.医学生物化学[M].北京:人民卫生出版社,1998.216-217.