张祎,李春梅,吴春华,陈秋,尚海花,王涛
ZHANG Yi,LI Chun-mei,WU Chun-hua,CHEN Qiu,SHANG Hai-hua,WANG Tao(Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin

• 1:天津市中药化学与分析重点实验室

摘要(Abstract)：

目的研究中药北刘寄奴(Siphonostegia chinensis Benth.)的化学成分。方法采用正相硅胶、反相ODS、Sephadex LH-20等柱色谱及高效液相色谱等手段进行分离纯化,并通过理化性质与光谱分析方法鉴定了化合物的结构。结果从北刘寄奴体积分数为95%的乙醇提取物中分离鉴定了8个黄酮类单体成分,分别为芹菜素(apigenin,1)、芹菜苷(apigentrin,2)、木犀草素(luteolin,3)、木犀草素-7-O-β-D-葡萄糖苷(luteolin-7-O-β-D-glucopyranoside,4)、槲皮素-3-O-β-D-葡萄糖苷(quer-cetin-3-O-β-D-glucopyranoside,5)、槲皮素-3-O-α-L-鼠李糖苷(quercetin-3-O-α-L-rhamnopyranoside,6)、isoscutellarein 8-glucuronide(7)、大豆素(daidzein,8)。结论其中化合物4～8为首次从阴行草属中分离得到。
Objective To study the chemical constituents from Siphonostegia chinensis Benth.Methods The compounds were isolated by chromatographic ways such as silica gel,ODS,Sephadex LH-20 and HPLC,and identified by the chemical and physical methods,especially spectral analysis.Results Eight flavonoids were isolated.The structures of them were identified as apigenin(1),apigentrin(2),luteolin(3),luteolin-7-O-β-D-glucopyranoside(4),quercetin-3-O-β-D-glucopyranoside(5),quercetin-3-O-β-L-rhamnopyranoside(6),isoscutellarein 8-glucuronide(7)and daidzein(8).Conclusions Among them,4-8 are obtained from Siphonostegia genus for the first time.

关键词(KeyWords)： 阴行草属;北刘寄奴;黄酮;化学成分;结构鉴定
Siphonostegia genus;Siphonostegia chinensis Benth.;flavonoid;chemical contituent;structure identification

Abstract:

Keywords:

基金项目(Foundation): 国家自然基金资助项目(81173524);; 天津市高等学校科技发展基金计划资助项目(20090201);; 国家科技重大专项资助项目—重大新药创制(2011ZX09307-002-01,2012ZX09103201-031)

作者(Author): 张祎,李春梅,吴春华,陈秋,尚海花,王涛
ZHANG Yi,LI Chun-mei,WU Chun-hua,CHEN Qiu,SHANG Hai-hua,WANG Tao(Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin

DOI: 10.14066/j.cnki.cn21-1349/r.2012.06.002

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