许环军,康帅涛,李晓东,战德胜,黄健,王金辉
XU Huan-jun,KANG Shuai-tao,LI Xiao-dong,ZHAN De-sheng,HUANG Jian,WANG Jin-hui(School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院

摘要(Abstract)：

目的改进苄基保护的α-D-葡萄糖三氯乙酰亚胺酯的合成工艺及分离方法。方法 D-葡萄糖经过甲基化、苄基保护、水解,与三氯乙腈生成三氯乙酰亚胺酯的活性给体。结果与结论高效合成并采用碱化的硅胶进行柱色谱分离得到苄基保护的α-D-葡萄糖三氯乙酰亚胺酯。这种分离方法可以运用于苄基保护的其他三氯乙酰亚胺酯的分离,也可以运用于其他保护基得到的三氯乙酰亚胺酯的分离纯化。
Objective To improve the synthetic process and separation method of benzyl-protected α-D-glucopyranosyl trichloroacetimidate.Methods Benzyl-protected α-D-glucopyranosyl trichloroacetimidate was prepared from D-glucose through methylation,benzyl protection,hydrolysis and reaction with trichloroacetonitril.Results and Conclusions Benzyl-protected α-D-glucopyranosyl trichloroacetimidate is efficiently synthesized and isolated through column chromatography processed by alkaline gel.This purification method can be applied to benzyl-protection sugars and trichloroacetimidates.

关键词(KeyWords)： 苄基保护的α-D-葡萄糖三氯乙酰亚胺酯;合成工艺;分离方法
benzyl-protected α-D-glucopyranosyl trichloroacetimidate;synthetic process;purification method

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 许环军,康帅涛,李晓东,战德胜,黄健,王金辉
XU Huan-jun,KANG Shuai-tao,LI Xiao-dong,ZHAN De-sheng,HUANG Jian,WANG Jin-hui(School of Traditional Chinese Materia Medica

DOI: 10.14066/j.cnki.cn21-1349/r.2012.05.002

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