马来酸罗格列酮的合成工艺改进An improved synthesis of rosiglitazone maleate
付晔,王绍杰,张为革,许越
FU Ye; WANG Shao jie; ZHANG Wei ge; XU Yue (Department of Pharmaceutics;
摘要(Abstract):
对马来酸罗格列酮的合成方法进行改进 ,5步反应总收率为 2 8 6 %
Rosiglitazone maleate was synthesized through an improved method.The total yield was improved from 13 1% to 28 6%.
关键词(KeyWords):
抗糖尿病药;马来酸罗格列酮;合成
antidiabetic drug; rosiglitazone maleate; synthe?
基金项目(Foundation):
作者(Authors):
付晔,王绍杰,张为革,许越
FU Ye; WANG Shao jie; ZHANG Wei ge; XU Yue (Department of Pharmaceutics;
参考文献(References):
- [1]SorberaLA ,RabassedaX ,CastanerJ ,etal.Rosiglita zoneMaleate [J].DrugoftheFuture ,1998,2 3(9) :977 985 .
- [2 ]BarrieCCCantello ,MichaelACawthorne ,GrahamPCottam ,etal.[[ω (Heterocyclylamino)alkoxy]ben zyl] 2 ,4 thiazolidinedionesaspotentantihyperglycemicagents [J].MedChem ,1994,37:3977 3985 .
- [3]RichardMHindley .Preparationof 5 [[(heterocy clylamino)ethoxy]benzylidene] 2 ,4 thiazolidinedionesasantihyperglycemicsandantihyperlipidemics [P].USPatent :5 0 0 2 95 3 .1991 0 3 2 6 (CA 115 :49719y) .
- [4 ]PoolColinRipley ,RomanRobinsherwood ,BriyhwellMalcolomDavid ,etal.Thiazolidinedionederivatives[P].WOPatent :940 5 ,6 5 9.1994 0 3 17(CA 12 0 :32 35 6 4c) .