海洋真菌Y26-02的灰黄霉素类化学成分Griseofulvin constituents from marine fungus Y26-02
吴红华,田黎,沙沂,孙莎,王亚男,裴月湖
WU Hong-hua1,TIAN Li2,SHA Yi3,SUN Sha1,WANG Ya-nan1,PEI Yue-hu1(1.School of Traditional Chinese Materia Medica
摘要(Abstract)：
目的研究海洋真菌Y26-02发酵液的乙酸乙酯萃取部分,对其中的化学成分进行分离鉴定。方法采用硅胶、Sephadex LH-20柱色谱以及制备型高效液相色谱等手段进行分离纯化,通过理化性质和各种波谱数据对这些化合物进行结构鉴定。结果从海洋真菌Y26-02菌液的乙酸乙酯萃取部分分离得到7个化合物,分别鉴定为灰黄霉素(griseofulvin,1)、表灰黄霉素(epigriseofulvin,2)、异灰黄霉素(isogriseofulvin,3)、脱氯表灰黄霉素(dechloroepigriseofulvin,4)、脱氢灰黄霉素(de-hydrogriseofulvin,5)、4′-丁氧基异灰黄霉素(4′-butoxyisogriseofulvin,6)、2′-丁氧基表灰黄霉素(2′-butoxyepigriseofulvin,7)。结论这7个化合物均为首次从该真菌的代谢产物中分离得到,其中化合物6、7是新天然产物。
Objective To isolate and identify the chemical constituents of the ethyl acetate extract part of the marine fungus Y26-02 fermentation broth.Methods The compounds were isolated by silica gel column,Sephadex LH-20 column chromatography and HPLC techniques.And these compounds were identified by the physico-chemical properties and spectral analysis.Results Seven compounds were obtained and identified as griseofulvin(1),epigriseofulvin(2),isogriseofulvin(3),dechloroepigriseofulvin(4),dehydrogriseofulvin(5),4′-butoxyisogriseofulvin(6)and 2′-butoxyepigriseofulvin(7).Conclusions All mentioned compounds are firstly isolated from the fungus Y26-02.Compounds 6,7 are isolated from natural products for the first time.
关键词(KeyWords)：
海洋真菌;灰黄霉素;化学成分;结构鉴定
marine fungus;griseofulvin;chemical constituent;structure identification
基金项目(Foundation): 国家“863”项目(2007AA09Z413,2007AA09Z435);; 国家自然科学基金(40776098)
作者(Author):
吴红华,田黎,沙沂,孙莎,王亚男,裴月湖
WU Hong-hua1,TIAN Li2,SHA Yi3,SUN Sha1,WANG Ya-nan1,PEI Yue-hu1(1.School of Traditional Chinese Materia Medica
DOI: 10.14066/j.cnki.cn21-1349/r.2010.04.008
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