吴晶晶,左莉华,姜珍,郭兴杰
WU Jing-jing,ZUO Li-hua,JIANG Zhen,GUO Xing-jie(School of Pharmacy

• 1:沈阳药科大学药学院

摘要(Abstract)：

目的以磺化-β-环糊精(S-β-CD)为手性选择剂,建立毛细管区带电泳法分离文拉法辛、奥昔布宁、维拉帕米、萘哌地尔、氟西汀对映体。方法采用未涂壁熔融石英毛细管柱,磷酸二氢钠缓冲溶液为背景电解质,分离电压为-15 kV,考察了环糊精质量浓度、缓冲溶液的pH值、缓冲盐浓度对对映体分离的影响。结果在最优的电泳条件下5种药物均达到基线分离。结论 S-β-CD是一种具有较强分离选择性的手性选择剂。
Objective To separate the enantiomers of oxybutynin,naftopidil,venlafaxine,fluoxetine and verapamil by capillary electrophoresis with sulfated-β-cyclodextrin(S-β-CD)as a chiral selector.Methods The separation of the enantiomers was performed in a fused-silica capillary tube,in the buffer of NaH2PO4 with the voltage of-15 kV.S-β-CD content,buffer pH and concentration were studied and optimized.Results Baseline separation of the five analytes was achieved in the best situation.Conclusions It is proved that S-β-CD is a good chiral selector for the separation of drugs.

关键词(KeyWords)： 磺化-β-环糊精;拆分;毛细管电泳;文拉法辛;奥昔布宁;维拉帕米;萘哌地尔;氟西汀
sulfated-β-cyclodextrin;enantioseparation;capillary electrophoresis;venlafaxine;oxybutynin;verapamil;naftopidil;fluoxetine

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 吴晶晶,左莉华,姜珍,郭兴杰
WU Jing-jing,ZUO Li-hua,JIANG Zhen,GUO Xing-jie(School of Pharmacy

DOI: 10.14066/j.cnki.cn21-1349/r.2012.10.012

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