黄艺,罗素兰,长孙东亭
HUANG Yi,LUO Su-lan,ZHANGSUN Dong-ting

• 1:海南大学热带生物资源教育部重点实验室海口市海洋药物重点实验室
• 2:海南大学农学院

摘要(Abstract)：

目的近几十年,肌肉型乙酰胆碱受体(nicotinic acetylcholine receptors,nAChRs)成为神经生理学、药理学、药物设计及相关疾病研究的重要靶点。包括横纹肌肉瘤、小儿软组织瘤、肌源性紊乱等疾病都与肌肉型nAChRs的异常有关。因此寻找针对肌肉型nAChRs的特异性探针,对于研究受体的结构、功能及相关疾病发病机理与治疗药物研发至关重要。方法通过查阅相关文献对近年来发现的特异作用于肌肉型nAChRs的生物毒素进行了综述。结果与结论自然界中存在许多天然生物毒素,能特异作用于肌肉型nAChRs,这些毒素对于研究肌肉型nAChRs的结构和功能,以及相关疾病的诊断和治疗有着非常重要的应用价值。
Objective In recent decades,muscle-type nicotinic acetylcholine receptors(n AChRs) are explored as the research target of neurophysiology,pharmacology,drug design and related diseases research.For example,rhabdomyosarcoma,a pediatric soft-tissue cancer,muscle tissue associated with various neurogenic and myogenic disorders are all related to the pathological expression of muscle-type n AChRs.Therefore,searching the specific probes to target muscle type n AChRs is crucial for the study on the structure,function and the pathogenesis of the muscle-type n AChRs.and also important for the discovery of drug to treat n AChRs related diseases.Methods This paper has reviewed research progress of biological toxins targeting muscle-type n AChRs in recent years.Results and Conclusions In nature,there are many biotoxins with pontential action on muscle-type n AChRs,and they can play an important role in studying the structure and functions of muscle-type n AChRs,as well as the diagnosis and treatment of related diseases

关键词(KeyWords)： 肌肉型乙酰胆碱受体;芋螺毒素;蛇毒;蜘蛛毒素;水母毒素;生物碱毒素
muscle type nicotinic acetylcholine receptors;conotoxins;snake venom toxin;spider venom toxin;jellyfish venom toxins;alkaloids

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(41366002);; 长江学者和创新团队发展计划资助项目(IRT_15R15)

作者(Author): 黄艺,罗素兰,长孙东亭
HUANG Yi,LUO Su-lan,ZHANGSUN Dong-ting

DOI: 10.14066/j.cnki.cn21-1349/r.2017.01.016

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