氟代胆碱类化合物的合成及其抗肿瘤活性的研究Synthesis and anti-tumor activity of fluorocholine compounds
温鸿亮,王世真,王千里
WEN Hong liang 1; WANG Shi zhen 1; WANG Qian li 2 (1 PUMC Hospital;
摘要(Abstract)：
以甲二醇二对甲苯磺酸酯和重氮乙酸乙酯为起始原料 ,经取代、还原、甲基化、磷酸化反应合成了 5个氟代胆碱类化合物 ,经1H NMR及质谱确证了结构 ,并进行了抗肿瘤活性的细胞筛选实验。结果表明这 5个化合物均具有一定的抗肿瘤活性。其中FC 3对 4种癌细胞均具有较好的抑制作用 ,值得进一步进行活性筛选
Five fluorocompounds were synthesized from ethyl diazoacetate or methanediol bis(4 methylbenzene sulfonate) via substitution,reduction,methylation and phosphatization. Their structures were identified by MS and 1H NMR . All of them showed anti tumor activities. In particular, compound FC 3 showed better inhibition activities to four cancer cells and it's worthy of further screening.
关键词(KeyWords)：
氟代胆碱;抗肿瘤;合成
fluorocompounds; anti tumor; synthesis
基金项目(Foundation):
作者(Authors):
温鸿亮,王世真,王千里
WEN Hong liang 1; WANG Shi zhen 1; WANG Qian li 2 (1 PUMC Hospital;
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