哌拉西林钠对甲磺酸帕珠沙星在大鼠体内药代动力学的影响Effect of piperacillin sodium on pharmacokinetics of pazufloxacin mesilate in rats
刘茜,梁明杰,赵辉,纪庆月,刘丹,郭孟楠
LIU Qian,LIANG Ming-jie,ZHAO Hui,JI Qing-yue,LIU Dan,GUO Meng-nan(School of Pharmacy
摘要(Abstract)：
目的研究哌拉西林钠对甲磺酸帕珠沙星在大鼠体内药代动力学的影响。方法 12只健康雄性SD大鼠随机分成2组(分别为单独和联合给药组),用HPLC法测定血浆中甲磺酸帕珠沙星的浓度。结果单独用药与联合用药组ρmax分别为(33.54±4.68)和(37.83±3.43)mg.L-1,AUC0-t分别为(43.32±15.91)和(41.98±9.19)mg.h.L-1,t1/2分别为(1.00±0.31)和(0.80±0.24)h,无显著性差异(P>0.05)。结论与哌拉西林钠联合用药后甲磺酸帕珠沙星在大鼠体内的药动学参数均不存在显著性差异。
Objective To investigate the effect of piperacillin sodium on pharmacokinetics of pazufloxacin mesilate in rats.Methods Twelve healthy male SD rats were divided into two groups(i.v.pazufloxacin mesilate alone and combination of piperacillin sodium and pazufloxacin mesilate),the plasma concentrations of pazufloxacin mesilate were determined by HPLC.Results The pharmacokinetics parameters of pazufloxacin mesilate in healthy rats after i.v.pazufloxacin mesilate alone and combination of piperacillin sodium and pazufloxacin mesilate were as follow:ρmax were(33.54±4.68) and(37.83±3.43)mg · L-1,AUC0-t were(43.32±15.91) and(41.98±9.19)mg · h · L-1;t1/2 were(1.00±0.31) and(0.80±0.24)h,which showed no significance difference between the two groups(P>0.05).Conclusions There are no significant differences about pharmacokinetic parameters between pazufloxacin mesilate alone and combination of piperacillin sodium in SD rats.
关键词(KeyWords)：
哌拉西林钠;甲磺酸帕珠沙星;药代动力学
piperacillin sodium;pazufloxacin mesilate;pharmacokinetics
基金项目(Foundation):
作者(Author):
刘茜,梁明杰,赵辉,纪庆月,刘丹,郭孟楠
LIU Qian,LIANG Ming-jie,ZHAO Hui,JI Qing-yue,LIU Dan,GUO Meng-nan(School of Pharmacy
DOI: 10.14066/j.cnki.cn21-1349/r.2012.04.010
参考文献(References)：
- [1]NOMURA N,MITSUYAMA J,FURUTA Y,et al.In vitroand in vivo antibacterial activity of pazufloxacin mesil-ate,a new injectable quinolone[J].Jpn J Antibiot,2002,55(4):412-439.
- [2]钟倩.抗菌药-甲磺酸帕珠沙星[J].世界临床药物,2004,2(25):122-123.
- [3]SHARON S C.Piperacillin[OB/OL].http://www.sciencedirect.com/science/article/pii/B9780080552323624250,2011-04-12.
- [4]MACEDO T R A,CARRINGTON COSTA R,FON-TES RIBEIRO C A,et al.Pharmacokinetic parametersand clinical evaluation of piperacillin and pefloxacin inpatients from an intensive care unit[J].EuropeanJournal of Pharmacology,1990,183(6):2373-2374.
- [5]王睿,李芹,裴斐,等.中国健康志愿者多次静滴甲磺酸帕珠沙星注射液药动学研究[J].中国药学杂志,2006,4l(11):850-853.
- [6]王宪冈,苗佳,梁德荣,等.甲磺酸帕珠沙星注射液临床药代动力学/药效学研究[J].四川大学学报(医学版),2009,40(4):689-693.