陈济氏;姚崇舜;李志江;庄继生;
Chen Jimin Yao Chongshun Shenyang College of pharmacy Li Zhijiang Zhuang Jisheng Anyan The First Pharmaceutical Factory

• 1: 沈阳药学院
• 2:沈阳药学院
• 3:安阳第一制药厂
• 4:安阳第一制药厂

摘要(Abstract)：

复方静脉乳剂静脉注射后,在家兔体内药物动力学特征呈现为双隔室开放模型,α=0.343分^(-1),t_1/2α=2分,β=0.0672分(-1),t_1/2α=2分,β=0.0672分^(-1),t_1/2β=10.3分。小白鼠静注后,在小肠、直肠、脾、胃组织中维持较长时间,2小时后仍有可测得的浓度。
After intravenous administration of 5-fluorouracil composite emulsion in rabbits, 5-fluorouracil confers the pharmacokinetic characteristics of a two-compartment model on body. α=0.343min(-1),t_1/2β=10.3分。小白鼠静注后,在小肠、直肠、脾、胃组织中维持较长时间,2小时后仍有可测得的浓度。
After intravenous administration of 5-fluorouracil composite emulsion in rabbits, 5-fluorouracil confers the pharmacokinetic characteristics of a two-compartment model on body. α=0.343min^(-1), t_(1/2α)=2min, β=0.0672min(-1), t_(1/2α)=2min, β=0.0672min^(-1), t_(1/2β)=10.3min. After intravenous administration in mice, the tissue distribution of 5-fluorouracil shows that it maintains a longer period in small intestine,straight intestine,spleen, stomach, and still has a determinable level after 2 hours.

关键词(KeyWords)： 5-氟脲啶嘧;乳剂;药物动力学;体内分布
Fluorouracil; Emulsion; Pharmacokinetics; Distribution

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 陈济氏;姚崇舜;李志江;庄继生;
Chen Jimin Yao Chongshun Shenyang College of pharmacy Li Zhijiang Zhuang Jisheng Anyan The First Pharmaceutical Factory

参考文献(References)：

• 1． 林超鸿等:肿瘤防治研究 10(3) :169,1983
• 2． Unno K, et al: Byoin Yakgaku 6(1) : 14, 1980
• 3． Colline JM, et al: Clin Pharmacol Therap 28:235, 1980
• 4． Cano JP, et al: Bull Cancer 66:67, 1979
• 5． Christophidis N, et al: Clin Pharmacokinet 3:330,1978
• 6． Clarkson B, et al: Clin Pharmacol Ther 3:447, 1964
• 7． Cohen JL, et al: Cancer Chem Rep 58:723, 1974
• 8． Finch RE, et al: Br J Clin Pharmacol 7:613, 1979
• 9． Finn C, et al: Cancer Chem Rep 59:279, 1975
• 10． Garrett ER, et al: J Pharm Sci 66:1422, 1977
• 11． MacMillan WE, et al: Cancer Res 38:3479, 1978
• 12． Sitar DS, et al: Cancer Rew 37:3981, 1977
• 13． 河野杉等:医学 110(1) :40,1979
• 14． Mukherjee KL, et al: Cancer Res 23:49, 1963