石媛,周福军,单淇,侯文彬,袁久志
SHI Yuan,ZHOU Fu-jun,SHAN Qi,HOU Wen-bin,YUAN Jiu-zhi

• 1:沈阳药科大学中药学院
• 2:天津药物研究院

摘要(Abstract)：

目的对胡桃科黄杞属植物黄杞(Engelhardtia roxburghiana Wall.)叶的脂溶性部分的化学成分进行研究。方法采用硅胶柱色谱、ODS柱色谱、制备高效液相色谱等多种方法分离单体化合物,通过波谱数据分析鉴定其结构。结果分离得到9个化合物,分别鉴定为白果酚(ginkgol,1)、α-tocopherylquinone(2)、cassipourol(3)、催吐萝芙木醇(vomifoliol,4)、去氢催吐萝芙木醇(dehydrovomifoliol,5)、花旗松素(taxilfolin,6)、2-甲氧基胡桃醌(2-methoxyjuglone,7)、2-乙氧基胡桃醌(2-ethoxyjuglone,8)和β-谷甾醇(β-sitosterol,9)。结论化合1~5为首次从黄杞属植物中分离得到。
Objective To study the chemical constituents of lipophilic extract from the leaves of Engelhardtia roxburghiana Wall.Methods Chromatographic methods were used for the isolation and purification,including silica gel,ODS and HPLC method.The structure of isolated copounds was elucidated on the basis of spectroscopic analysis.Results Nine compounds were obtained and identified as ginkgol(1),α-tocopherylquinone(2),cassipourol(3),vomifoliol(4),dehydrovomifoliol(5),taxilfolin(6),2-methoxyjuglone(7),2-ethoxyjuglone(8),and β-sitosterol(9).Conclusions Compounds 1- 5 are isolated from genus Engelhardia for the first time.

关键词(KeyWords)： 黄杞;倍半萜类;二萜类;白果酚;催吐萝芙木醇;去氢催吐萝芙木醇;cassipourol;α-tocopherylquinone
Engelhardtia roxburghiana;sesquiterpenes;diterpenoids;ginkgol;vomifoliol;dehydrovomifoliol;cassipourol;α-tocopherylquinone

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 石媛,周福军,单淇,侯文彬,袁久志
SHI Yuan,ZHOU Fu-jun,SHAN Qi,HOU Wen-bin,YUAN Jiu-zhi

DOI: 10.14066/j.cnki.cn21-1349/r.2017.01.005

参考文献(References)：

• [1]广西壮族自治区食品药品监督管理局.广西壮族自治区壮药质量标准:第二卷[M].南宁:广西科学技术出版社,2011:178.
• [2]饶伟源.壮药罗汉茶研究进展[J].广西医学,2015,37(7):956-959.
• [3]孙彤.黄杞叶和白菜化学成分研究[D].北京:北京协和医学院,2012:5-8.
• [4]王杰,余碧玉,刘向龙,等.银杏外种皮化学成分的分离和鉴定[J].中草药,1995,26(6):290-292.
• [5]ITOKAWA H,TOTSUKA N,NAKAHARA K,et al.Antitumor principles from Ginkgo biloba L.[J].Chemical and Pharmaceutical Bulletin,1987,35(7):3016-3020.
• [6]OLSON G L,CHEUNG H C,MORGAN K,et al.A newsynthesis ofα-tocopherol[J].Journal of Organic Chemistry,1980,45(5):803-805.
• [7]JUTIVIBOONSUK A,ZHANG Hong-jie,KONDRATYUK T P,et al.Isolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiae[J].Pharmaceutical Biology,2007,45(3):185-194.
• [8]赵明,吴霜,李军,等.猫眼草化学成分研究[J].中国中药杂志,2014,39(12):2289-2294.
• [9]NAIR J J,MULAUDZI R B,CHUKWUJEKWU J C,et al.Antigonococcal activity of Ximenia caffra Sond.(Olacaceae)and identification of the active principle[J].South African Journal of Botany,2013,86(3):111-115.
• [10]KISIELA W,MICHALSKAA K,SZNELER E,et al.Norisoprenoids from aerial parts of Cichorium pumilum[J].Biochemical Systematics and Ecology,2004,32(3):343-346.
• [11]LEE E H,KIM H J,SONG Y S,et al.Constituents of the stems and fruits of Opuntia ficus-indica var.saboten[J].Archives of Pharmacal Research,2003,26(12):1018-1023.
• [12]周媛媛,蒋艳秋,孟颖,等.青龙衣活性部分的化学成分研究[J].中成药,2015,37(2):332-335.
• [13]庄鹏宇,付文卫,谭昌恒,等.醉魂藤的化学成分研究[J].天然产物研究与开发,2009,21(6):963-965.