刘少彬;胡海洋;赵秀丽;乔明曦;王文宇;陈大为;
LIU Shao-bin,HU Hai-yang,ZHAO Xiu-li,QIAO Ming-xi,WANG Wen-yu,CHEN Da-wei(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

• 1:沈阳药科大学药学院

摘要(Abstract)：

目的制备长春西汀固体脂质纳米粒,为长春西汀新型给药系统的开发与应用提供实验基础。方法以长春西汀为模型药物、山嵛酸甘油酯为载体材料,采用热熔超声法制备长春西汀固体脂质纳米粒,并通过正交试验设计对处方进行优化。以包封率为评价指标,对其形态、体外释放度、短期稳定性等性质进行了考察。结果制备的纳米粒为球形及类球形,粒径为152.3 nm,包封率为93.68%,72 h体外累积释放71.84%,4℃下放置2个月稳定。结论热熔超声法可用于制备长春西汀固体脂质纳米粒,该纳米粒具有明显的缓释特征,可进一步进行体内释药行为的考察。
Objective To prepare vinpocetine solid lipid nanoparticles(SLN) and provide the basis for the development and application of new drug delivery of VIN-SLN.Methods The vinpocetine solid lipid nanoparticles were prepared by melt-emulsification-ultrasound method.The formulation was optimized by the orthogonal design.With the entrapment efficiencies as reference,its morphology,drug release in vitro and short-period stability were investigated.Results The results showed that the nanoparticles were sphere and sphere-like with the mean size of 152.3 nm and the entrapment efficiencies was 93.68%.During 72 h,the cumulative release was 71.84%.The nanoparticles were stable for 2 months at 4 ℃.Conclusions Using the melt-enmulsification-ultrasound method,the preparation of vinpocetine solid lipid nanoparticles is highly feasible.VIN-SLN is obviously delayed release which shows it can be investigated further in vivo.

关键词(KeyWords)： 长春西汀;固体脂质纳米粒;热熔超声法;理化性质
vinpocetine;solid lipid nanoparticle;melt-emulsification-ultrasound method;physico-chemical property

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 刘少彬;胡海洋;赵秀丽;乔明曦;王文宇;陈大为;
LIU Shao-bin,HU Hai-yang,ZHAO Xiu-li,QIAO Ming-xi,WANG Wen-yu,CHEN Da-wei(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

DOI: 10.14066/j.cnki.cn21-1349/r.2010.05.018

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