文冠木正丁醇提取物的抗炎作用The anti-inflammatory effects of the n butanol extract of Xanthoceras sorbifolia Bunge
匡荣,包文芳,赵明宏,安宁飞,刘玉兰
KUANG Rong; BAO Wen fang; ZHAO Ming hong; AN Ning fei; LIU Yu lan (Department of Pharmacology;
摘要(Abstract):
文冠木正丁醇提取物对二甲苯致小鼠耳肿胀、蛋清致大鼠足肿胀、角叉菜胶致小鼠足肿胀、醋酸致小鼠腹腔毛细血管通透性增加、小鼠羧甲基纤维素囊中白细胞游走、小鼠棉球肉芽肿生长均有显著的抑制作用 ,同样剂量下 ,文冠木正丁醇提取物对角叉菜胶致去双侧肾上腺小鼠足肿胀仍有显著的抑制作用 ,且对小鼠肾上腺重量及肾上腺中维生素C的含量没有明显影响
The anti inflammatory effect of n butanol extract of Xanthoceras sorbifolia Bunge(BEX)was studied in this paper.The ear edema resulted from dimethyl benzene,paw edema induced by carrageenin,the increase of vascular permeability caused by acetic acid,the chemotaxis of WBC induced by CMC and the weight of cotton granuloma in mice and hind paw edema induced by fresh egg white in rats were inhibited significantly by ig BEX daily for 7 days,respectively.The carrageenin induced paw edema was also inhibited markedly in adrenal ectomiced mice.No changes in weight of adrenal and the concentration of vitamin C were observed,indicating that the anti inflammatory effect of BEX was not related to pituitary adrenal system.
关键词(KeyWords):
文冠木正丁醇提取物;抗炎作用;去肾上腺小鼠
n butanol extract of Xanthoceras sorbifolia Bunge; anti inflammation; adrenal ectomiced mi?
基金项目(Foundation):
作者(Authors):
匡荣,包文芳,赵明宏,安宁飞,刘玉兰
KUANG Rong; BAO Wen fang; ZHAO Ming hong; AN Ning fei; LIU Yu lan (Department of Pharmacology;
参考文献(References):
- [1]中国医学科学院药用植物资源开发研究所 .中药志[M].第Ⅴ册 .北京 :人民卫生出版社 ,1993 .5 5 1 5 5 6 .
- [2 ]马建元 ,赵刚 ,李惠英 ,等 .爽咽茶主要药效学研究[J].中药新药与临床药理 ,1998,9(2 ) :99 10 0 .
- [3]曾南 ,沈映君 ,刘旭光 ,等 .荆介挥发油抗炎作用研究[J].中药药理与临床 ,1998,14(6 ) :2 4 2 6 .
- [4 ]陈奇 .中药药理研究方法学 [M ].北京 :人民卫生出版社 ,1994.30 3 30 5 .
- [5 ]何俏军 ,王立明 ,楼宜嘉 ,等 .虎梅含片对急性炎症的抗炎作用 [J].中成药 ,1998,2 0 (6 ) :34 35 .
- [6 ]连其深 ,张志祖 ,胡晓 ,等 .花椒毒酚抗炎作用的实验研究 [J].中草药 ,1998,2 9(2 ) :10 2 10 3 .
- [7]李仪奎 .中药药理实验方法学 [M ].上海 :上海科学技术出版社 ,1991.2 33 2 34.
- [8]陈奇 .中药药理研究方法学 [M ].北京 :人民卫生出版社 ,1994.35 6 35 7.
- 文冠木正丁醇提取物
- 抗炎作用
- 去肾上腺小鼠
n butanol extract of Xanthoceras sorbifolia Bunge - anti inflammation
- adrenal ectomiced mi?
- 匡荣
- 包文芳
- 赵明宏
- 安宁飞
- 刘玉兰
KUANG Rong - BAO Wen fang
- ZHAO Ming hong
- AN Ning fei
- LIU Yu lan (Department of Pharmacology
- 匡荣
- 包文芳
- 赵明宏
- 安宁飞
- 刘玉兰
KUANG Rong - BAO Wen fang
- ZHAO Ming hong
- AN Ning fei
- LIU Yu lan (Department of Pharmacology