王立波,王健伟,甘春丽,吴立军,刘凤芝
WANG Li-bo1,WANG Jian-wei1,GAN Chun-li1,WU Li-jun2,LIU Feng-zhi1 (1.School of Pharmacy

• 1:哈尔滨医科大学药学院
• 2:沈阳药科大学中药学院

摘要(Abstract)：

目的研究沙生蜡菊花降脂活性部位的化学成分。方法采用硅胶、ODS、制备HPLC等多种色谱方法分离纯化,依据理化性质、波谱数据分析进行结构鉴定。结果从沙生蜡菊花的降脂活性部位中分离得到了6个化合物,并分别鉴定为1个香豆素类化合物:东莨菪苷(scopolin,1),2个木脂素类化合物:tortoside B(2)(,7S,8R)-dihydrodehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside(3),2个查耳酮类化合物:chalonaringenin-2'-O-β-D-glucopyranoside(4),chalonaringenin-2',4'-O-β-D-glucopyranoside(5)1,个橙酮类化合物:金鱼草素6-O-β-D-吡喃葡萄糖苷(aureusidin-6-O-β-D-glucopyranoside,6)。结论化合物1-6均为从蜡菊属中首次分离得到。
Objective To study the chemical constituents in the fraction of lipid-lowering of Helichrysi arenarii Flos. Methods The chemical constituents were isolated by various methods of isolation(silica gel,ODS and HPLC column chromatography)and their structures were elucidated by the analysis of spectral data and chemical properties. Results Six compounds were identified as scopolin( 1),tortoside B( 2),(7S,8R)-dihydrodehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside( 3),chalonaringenin-2′-O-β-D-glucopyranoside( 4),chalonaringenin-2′,4′-O-β-D-glucopyranoside( 5),and aureusidin-6-O-β-D-glucopyranoside( 6). Conclusions Compounds 16 were obtained from Helichrysum Mill.for the first time.

关键词(KeyWords)： 沙生蜡菊花;降脂活性部位;化学成分;结构鉴定
Helichrysi arenarii Flos;fraction of lipid-lowering;chemical constituents;structural determination

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省教育厅科学技术研究项目(No.11551279)

作者(Author): 王立波,王健伟,甘春丽,吴立军,刘凤芝
WANG Li-bo1,WANG Jian-wei1,GAN Chun-li1,WU Li-jun2,LIU Feng-zhi1 (1.School of Pharmacy

DOI: 10.14066/j.cnki.cn21-1349/r.2011.11.002

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