杜广盛,李德馨,魏振平
DU Guang-sheng1,2,LI De-xin2

• 1:天津大学化工学院
• 2:天津天士力集团化学药物研究所

摘要(Abstract)：

目的综述聚乙二醇1000维生素E琥珀酸酯(D-α-tocopherol polyethylene glycol 1000 succi-nate,TPGS)在各种纳米制剂中的最新进展。方法查阅国内外相关文献共48篇,对这些文献进行分析、概括和总结。结果 TPGS能够提高药物包封率和细胞吸收,改善药物释放,提高药物生物利用度,并能协同起抗癌疗效。广泛应用于聚合物纳米粒、聚合物胶束、纳米脂质体、纳米药物等纳米给药系统中。结论 TPGS在纳米制剂中有着良好应用前景。
Objective To summarize the recent advances and discuss the future development of TPGS in nano drug delivery systems.Methods The related literatures and patents were consulted and the recent advances were summarized.Results TPGS could increase the drug encapsulation efficiency and cellular uptake,improve the property of drug release,enhance the drug oral bioavailability,and synergistically enhance the toxicity for cancer cells.It was widely utilized in nanometer drug delivery systems such as polymeric nanoparticles,polymeric micelles,nanometer liposomes and drug nanoparticles or nanosuspensions.Conclusions TPGS has broad prospects in nano drug delivery systems.

关键词(KeyWords)： 聚乙二醇1000维生素E琥珀酸酯;纳米制剂;表面活性剂
D-α-tocopherol polyethylene glycol 1000 succinate;nano drug delivery systems;surfactant

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 杜广盛,李德馨,魏振平
DU Guang-sheng1,2,LI De-xin2

DOI: 10.14066/j.cnki.cn21-1349/r.2012.12.017

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