沈阳药科大学学报

1985, (02) 125-127

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合成前列腺素E_1的中间体-γ亚麻酸甲酯的制备
PREPARATION OF THE INTERMEDIATE MATERIAL FOR SYNTHESIZING PROSTGLANDIN E_1 FROM PLANT RESOURCES—METHYL γ-LINOLENATE

高雅琴,李霞冰,朱廷儒
Gao Yaqin Li Xiabing Zhu Tingru Institute of Forestry and Pedology,Academia Sinica,Shenyang

摘要(Abstract):

以r-亚麻酸甲酯为原料可合成二高-r-亚麻酸,再经生物合成得前列腺素E_1。本文报道了由月见草(Oenothera biennis)种子油制备 r-亚麻酸甲酯的方法。所得产品为无色或微带黄色的油状液体,含有 r-亚麻酸60%(GLC)以上。按月见草油计算,总收率约3%。
Dihomo-γ-Linolenic acid was obtained chemically using methyl γ-linolenate as starting material.It could then be converted into prostglandin E_1 through bio- synthesis.In this paper,a modern method for preparing methyl γ-linolenate from the seed oil of Oenothera biennis was reported.The product obtained was a col- ourless or light yellowish oil.The content of γ-linolenic acid was higher than 60%(GLC).The total yield was about 3% caculated on the weight of the seed oil.

关键词(KeyWords): 月见草;r-亚麻酸;r-亚麻酸甲酯;二高-r 亚麻酸;前列腺素 E_1
Oenothera biennis;γ-Linolenic acid;Methyl γ-1inolenate;Dihomo-γ-linolenic acid;Prostaglandin E

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作者(Author): 高雅琴,李霞冰,朱廷儒
Gao Yaqin Li Xiabing Zhu Tingru Institute of Forestry and Pedology,Academia Sinica,Shenyang

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