新疆雪莲化学成分的分离与鉴定Isolation and identification of chemical constituents from whole plant of Saussurea involucrata Kar.et kir.
侯朋艺,黄健,孙博航,吴立军,高慧媛
HOU Peng-yi,HUANG Jian,SUN Bo-hang,WU Li-jun,GAO Hui-yuan(Key Laboratory of Structure-Based Drug Design & Discovery
摘要(Abstract)：
目的对新疆雪莲的化学成分进行研究。方法采用硅胶、凝胶柱色谱和重结晶等分离方法对体积分数为75%的新疆雪莲乙醇溶液提取物进行成分分离,通过谱学分析方法结合理化性质进行结构鉴定。结果共分离得到8个化合物,分别鉴定为大苞雪莲内酯(involucratolactone,1)、11α,13-dihydrozaluzanin-C(2)、dihydrozaluzanin-C(3)、7β-羟基谷甾醇(7β-hydroxysitosterol,4)、7β-羟基豆甾醇(stigmast-5,22-dien-3β,7β-diol,5)、山奈酚(kaempferol,6)、高车前素(hispidulin,7)、粗毛豚草素(jaceosidin,8)。结论化合物3、5为首次从风毛菊属植物中分离得到,化合物2、4为首次从新疆雪莲植物中分离得到。
Objective To study the chemical constituents of the whole plant of Saussurea involucrata Kar.et kir. Methods The chemical constituents of 75% ethanol extract of Saussurea involucrata Kar.et kir.were isolated by silica gel column chromatography,sephadex LH-20 column chromatography,together with recrystallization method,and the structures were identified by means of NMR spectral analysis and physico-chemical properties. Results Eight compounds were obtained and elucidated as involucratolactone(1),11α,13-dihydrozaluzanin-C(2),dihydrozaluzanin-C(3),7β-hydroxysitosterol(4),stigmast-5,22-dien-3β,7β-diol(5),kaempferol(6),hispidulin(7),jaceosidin(8),respectively. Conclusions Compounds 2,4 are isolated from this plant for the first time,while,compounds 3 and 5 are isolated from the Saussurea genus for the first time.
关键词(KeyWords)：
新疆雪莲;化学成分;结构鉴定
Saussurea involucrata Kar.et kir.;chemical constituent;structure identification
基金项目(Foundation): 国家“十一五”科技支撑计划课题(2007BAI30B03)
作者(Author):
侯朋艺,黄健,孙博航,吴立军,高慧媛
HOU Peng-yi,HUANG Jian,SUN Bo-hang,WU Li-jun,GAO Hui-yuan(Key Laboratory of Structure-Based Drug Design & Discovery
DOI: 10.14066/j.cnki.cn21-1349/r.2011.02.002
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