张冬松,高慧媛,吴立军
ZHANG Dong-song,GAO Hui-yuan,WU Li-jin(School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院
• 2:沈阳药科大学中药学院
• 3:沈阳药科大学中药学院 辽宁沈阳110016
• 4:辽宁沈阳110016

摘要(Abstract)：

目的对光皮木瓜的化学成分、药理活性及临床研究作以综述。方法查阅了35个中外文献,按照化合物的结构类型对光皮木瓜的化学成分进行分类综述,并且对其对其药理活性及临床应用加以总结。结果光皮木瓜含有多种化学成分,主要有有机酸类、甾类、三萜类、木脂素类、黄酮类等化合物,具有抗肿瘤,免疫调节,抗菌等多种生物活性,临床应用广泛。结论为中药光皮木瓜的研究与开发提供了参考。
Objective To review the studies on chemical constitutents,pharmacological activity and clinical applications of Chaenomeles sinensis.Methods Based on the chemical structural types of compounds,the constituents were reviewed respectively.The pharmacological effects and clinical applications were also summarized.Results The plant was proved to contain various chemical constituents,primarily including organic acids,steroid saponins,triterpenoids,lignans flavonoids,ect.It exhibited many bioactivities such as antitumor,immunosuppressive and antibacterial activity.Conclusions This review provides a reference for the further research and development of Chaenomeles sinensis.

关键词(KeyWords)： 光皮木瓜;化学成分;药理活性;临床应用
Chaenomeles sinensis;chemical constituents;pharmacological activity;clinical application

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张冬松,高慧媛,吴立军
ZHANG Dong-song,GAO Hui-yuan,WU Li-jin(School of Traditional Chinese Materia Medica

参考文献(References)：

• [1]中华本草编辑委员会.中华本草:第四卷[M].上海:科学技术出版社,1999:1151.
• [2]MIHARA S,TATEBA H,NISHIMURA O,et al.Volatile components of Chinese quince[J].J AgricFood Chem,1987,35(4):532-537.
• [3]洪永福,孙连娜,郭学敏,等.三种木瓜的乙醚提取部位的气相色谱-质谱分析[J].第二军医大学学报,2000,21(8):749-752.
• [4]史亚歌,刘拉平.光皮木瓜挥发油成分的GC-MS[J].西北农业学报,2005,14(3):163-166.
• [5]孙连娜,洪永福,郭学敏.光皮木瓜化学成分的研究Ⅱ[J].第二军医大学学报,1999,20(10):752-754.
• [6]ROH S B;CHANG E H;IM K S,et al.Isolation andcharacterization of acidic triterpenes from the fruits ofChaenomeles sinensis[J].Yakhak Hoeji,1995,39(2):610-615.
• [7]IM KS,ROH SB.Twp major triterrpene acids fromthe fruits of Chaenomeles sinensis Koehne[J].PusanBull Pharm Sci,1991,25(1):1.
• [8]高慧媛,吴立军,黑柳正典.光皮木瓜的化学成分[J].中国天然药物,2003,1(2):82-84.
• [9]杨自威.葛芍木瓜汤治疗神经根型颈椎病[J].甘肃中医,2004,17(6):18-20.
• [10]SUN L N,HONG Y F.Chemical constituents ofChaenomeles sinensis(Thouin)Koehne[J].J ChinPharm Sci,2000,9(1):6-9.
• [11]高慧媛,吴斌,李文.光皮木瓜的化学成分Ⅱ[J].中国天然药物,2004,2(6):351-353.
• [12]孙连娜,洪永福.简述中药木瓜的化学、药理与临床应用研究[J].药学实践杂志,1999,17(5):281-284.
• [13]LEE MH,SON YK,HAN YN.Tissue Factor inhibito-ry flavonoids from fruits of Chaenomeles sinensis[J].Archives of Pharmacal Research,2002,25(6):842-848.
• [14]VINCENT MW,LAWRENCE JP,RICHARD W.Molecular weight profile of proathocynidine polymers[J].Phytochemistry,1983,22(1):569-572.
• [15]HO KK,WON KJ,BYOUNG SK.Flavanone glycosidefrom the fruits of Chaenomeles sinensis[J].Nat ProdSci,2000,6(1):79-81.
• [16]GAO Hui-Yan,WU Li-jun,KUROYANAGI M.Anew compound from Chaenomeles sinensis(Thouin)Koehne[J].Chinese Chemical letters,2003,14(3):274-275.
• [17]MATSUO T,ITO SA.Simple and rapid purificationmethod of condensed tannis from several young fruits[J].Agric Biol Chem,1981,45(4):1884.
• [18]OSAWA KJ,ARAKAWA T,SHIMURA SB.Newquonic acid derivatives from the fruits of Chaenomelessinensis[J].Natural Medicines,2001,55(3):255-257.
• [19]田奇伟,唐召海,郭成立,等.木瓜的抗菌作用[J].微生物学通报,1982,6(1):271-272.
• [20]GAO Hui-Yan,WU Li-jun,KUROYANAGI M.Chemical constituents of Chaenomeles sinensis Koehne[J].Chemical&Pharmaceutical Bulletin,2003,51(11):1318-1321.
• [21]VALENTINA Z,ROSANNA S,SABINA CR,et al.Elective cytotoxicity of betulinic acid on tumor celllines,but not on normal cells[J].Cancer Letters,2002,175(1):17-25.
• [22]郑虎占.中药现代化研究与应用[M].北京:学苑出版社,1996:929-935.
• [23]王淑兰,李淑莲,董崇田,等.枸杞子等八种中药提取液对体外培养细胞和小鼠腹腔巨噬细胞影响的实验研究[J].白求恩医科大学学报,1990,16(4):325-328.
• [24]ZHANG Ling-ling,WEI Wei,YAN Shang-xue.Therapeutic effects of glucosides of Chaenomeles sinen-sis on collagen-induced arthritis in mice[J].ActaPharmacologica Sinica,2004,25(11):1495-1501.
• [25]郑智敏,王寿源.中药木瓜对大白鼠肝损伤的实验观察[J].福建中医药,1985,16(6):35-36.
• [26]田奇伟.木瓜舒肝冲剂治疗急性黄疸型肝炎的临床疗效分析[J].中草药,1989,20(2):4
• [27]罗兴长,丁家欣,张玲.126种抗凝血酶作用的实验观察[J].中草药,1987,18(4):21.
• [28]李生正,王文燕,张薇,等.中药木瓜的研究概况[J].陕西中医,2000,21(9):424.
• [29]孙连娜,洪永福,郭学敏,等.光皮木瓜化学成分研究[Ⅰ][J].中草药,1999,30(增刊):67-68.
• [30]郭成立,田昌木,唐召海,等.木瓜治疗急性细菌性痢疾107例临床观察[J].中华医学杂志,1984,64(11):689-690.
• [31]椹宁生,茅允兰,苏国基.肝灵冲剂治疗急性肝炎102例报告[J].中医杂志,1988,29(10):738.
• [32]曾庆平.术瓜二草汤治疗肝硬变腹水30例[J].陕西中医,1992,13(1):16-17.
• [33]赵玉海.加味芍药甘草汤治疗腓肠肌痉挛85例[J].中医杂志,1885,26(6):50.
• [34]徐磊.白芍木瓜汤治疗骨质增生症的体会[J].医学动物防制,2006,22(7):428-485.
• [35]杨自威.葛芍木瓜汤治疗神经根型颈椎病[J].甘肃中医,2004,17(6):18-20.