三嗪类衍生物的研究Syntheses of the derivatives of triazine
刘畅,宋爱华,周忠喜,曾昭钧
LIU Chang1; SONG Ai-hua2; ZHOU Zhong-xi3; ZENG Zhao-jun1 (1. School of Pharmaceutical Engineering;
摘要(Abstract)：
目的研究合成三嗪类衍生物。方法以二甲双胍为起始原料 ,生成三嗪类化合物。结果与结论合成 7个三嗪类化合物 ,所合成化合物通过1H NMR、MS确认其结构。期待此类化合物能够和二甲双胍一样具有降糖作用 ,并降低与其类似的不良反应。
Objective To synthesize triazine derivatives.Methods Triazine compounds were synthesized from metformin which is the prime material.Results and Conclusions Seven triazine compounds have been synthesized and their chemical structures have been confirmed by 1H-NMR and MS.Triazine compounds are expected to have the same role of metformin on diabetes mellitus and to reduce analogous adverse reactions of metformin.
关键词(KeyWords)：
二甲双胍;三嗪;合成
metformin; triazine; synthesize
基金项目(Foundation):
作者(Authors):
刘畅,宋爱华,周忠喜,曾昭钧
LIU Chang1; SONG Ai-hua2; ZHOU Zhong-xi3; ZENG Zhao-jun1 (1. School of Pharmaceutical Engineering;
参考文献(References)：
- [1]张翠欣,王中孝.降糖药的研究进展[J].中国药学杂志,2002,37(5):328-330.
- [2]SchenneAJ .Thetreatmentonnon-insulindepea-ndentdiabetesmellitusin1999s[J].Drugs,1997,54(3):355-368.
- [3]朱珠,孙忠实.认识新型口服降糖药[J].辽宁药物与临床,2002,5(3):121-123.
- [4]李后开.非胰岛素依赖性糖尿病的药物治疗及进展[J].安徽医药,2001,5(4):244-245.
- [5]纪莎,魏毅.口服降糖药的分类和特点[J].福建医药杂志,2001,23(6):119-120.
- [6]MaggsDG ,BuchananTA ,BurantCF ,etal.Mebaboliceffectsoftroglitazonemonotherapyintype2diabetesmellitus:aranodomized,double-mind,placebocon trolledtria[J].AnnInternMed,1998,128(3):176-185.
- [7]InzucchiSE ,MaggsDG ,SpollettGR ,etal.EfficacyandmetaboliceffectsofmetforminandtroglitazoneintypeIIdiabetesmellitus[J].NEnglJMed,1998,338(3):867-872.
- [8]KelarevVI,KarakhanovRA .Synthesisandpropertiesofderivativesofsymtriazine[J].KhimGeterofsiklSoedin,1992,(9):1250-1256.