沈阳药科大学学报

2004, (03) 207-209

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低分子肝素对大鼠局灶性脑缺血再灌注损害的保护作用
Experimental research for LMWH on the local cerebral ischemia-reperfusion injury in rats

秦献辉,李莹,何晓静,刘玉兰
QIN Xian-hui; LI Ying; HE Xiao-jing; LIU Yu-lan (School of Pharmacy;

摘要(Abstract):

目的探讨低分子肝素 (lowmolecularweightheparin ,LMWH)对局灶性脑缺血再灌注损害的保护作用及机制。方法用线栓法制备大鼠大脑中动脉缺血再灌注模型 ,以ZeaLonga 5分制法评分 ,再灌注 6h后测定大鼠脑组织中MDA含量、GSH Px及MPO活力。结果LMWH能明显改善行为障碍 ,提高GSH Px活力 ,降低MDA含量 ,减缓脑组织中MPO的升高。结论LMWH对大鼠脑缺血再灌注有保护作用 ,其机制可能与提高抗氧化酶活性、抗自由基损伤及抗炎等作用有关
Objective To investigate the protective effects of low molecular weight heparin(LMWH) on local cerebral ischemia-reperfusion(I-R) injuryed rats and its mechanism of action.Methods Animal models of local cerebral ischemia-reperfusion were made by thread.Zea Longa method was used to evaluate behavioral change.After 6 h reperfusion,the content of malondialdehyde(MDA),the activities of glutathione peroxidase(GSH-Px)and myeloperoxidase(MPO) in brain tissue were measured.Results Neurological deficits can be obviously decreased by LMWH.Compared with model group,LMWH protected the activity of GSH-Px,reduced the content of MDA and also inhibited the increase of MPO in brain tissue.Conclusion LMWH has protective effects on local ischemia-reperfusion(I-R) injuryed rat,and its mechanism may be related to increase the activity of antioxidase and reduce damage of oxygen free radicals and inflammation.

关键词(KeyWords): 局灶性脑缺血再灌注;行为学;自由基损伤;炎症反应
local cerebral ischemia-reperfusion; behavior; oxygen free radicals damage; inflammation

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作者(Authors): 秦献辉,李莹,何晓静,刘玉兰
QIN Xian-hui; LI Ying; HE Xiao-jing; LIU Yu-lan (School of Pharmacy;

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