王健,毕殿洲
WANG Jian, BI Dian zhou (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院 辽宁沈阳110016
• 3:辽宁沈阳110016

摘要(Abstract)：

目的系统地了解生物粘附材料的类别和性质 ,生物粘附的机理 ,影响生物粘附的因素 ,生物粘附性的实验研究方法 ,生物粘附材料在制剂中的应用及存在的问题。方法对近期的文献进行检索、分类和整理。结果对生物粘附传递系统的研究比较活跃 ,但性能优良的生物粘附材料的品种较少 ,生物粘附的机理尚不完全清楚 ,生物粘附性的实验研究方法有待于完善。结论生物粘附传递系统将具有较好的应用前景。
Objective To systematically introduce the classification and properties of bioadhesive materials,the mechanisms of bioadhesion,the factors that influence the bioadhesive behavior,the evaluation methods for bioadhesion,the application of bioadhesive materials in pharmaceutical dosage forms and the problems existed accordingly. Methods Consult the recent journals and books,and make integration. Results The bioadhesive drug delivery system is the interest of many pharmaceutical researchers. However,the number of bioadhesive materials with satisfied quality is far less enough,the mechanisms of bioadhesion are still not quite clear,and the methods for bioadhesion evaluation leave much room to improve. Conclusions Bioadhesive materials shall have a very good prospect in the drug delivery system.

关键词(KeyWords)： 生物粘附;粘膜粘附;生物粘附传递系统
bioadhesion; mucoadhesion; bioadhesive drug delivery system

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王健,毕殿洲
WANG Jian, BI Dian zhou (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

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