沈阳药科大学学报

2010, v.27;No.170(03) 195-199

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温郁金中倍半萜类成分的分离与鉴定
Sesquiterpenes from Curcuma wenyujin

楼燕,何昊,魏星川,李雪改,陈丽霞,邱峰
LOU Yan,HE Hao,WEI Xing-chuan,LI Xue-gai,CHEN Li-xia,QIU Feng(School of Traditional Chinese Materia Medica

摘要(Abstract):

目的对温郁金(Curcuma wenyujin)的化学成分进行研究。方法采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱,HPLC以及制备薄层色谱(P-TLC)进行分离和纯化,并依据理化性质和光谱学分析鉴定其化学结构。结果从温郁金的体积分数为50%的乙醇溶液提取物中分离得到6个倍半萜,分别鉴定为原莪术醇(procurcumenol,1)、环氧泽泻烯(alismoxide,2)、aeruginolac-tone(3)、(1E,4Z)-8-hydroxy-6-oxogermacra-1(10),4,7(11)-trieno-12,8-lactone(4)、1β,4α-di-hydroxy-5α,8β(H)-eudesm-7(11Z)-en-12,8-olide(5)和curcolonol(6)。结论其中化合物1、2为愈创木烷型倍半萜,3、4为吉玛烷型倍半萜,5、6为桉烷型倍半萜。化合物4、5均为首次从该属植物中分离得到,化合物1、2、3、6均为首次从本植物中分离得到。
Objective To study the chemical constituents from the dried rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling.Methods The constituents were purified by repeated column chromatography,including Silica gel,Sephadex LH-20 column,ODS column,HPLC and preparative-TLC(P-TLC).The structures of these compounds were elucidated by spectroscopic methods.Results Six sesquiterpenes were isolated from the dried rhizomes of C.wenyujin and identified as procurcumenol(1),alismoxide(2),aeruginolactone(3),(1E,4Z)-8-hydroxy-6-oxogermacra-1(10),4,7(11)-trieno-12,8-lactone(4),1β,4α-dihydroxy-5α,8β(H)-eudesm-7(11Z)-en-12,8-olide(5)and curcolonol(6),respectively.Conclusions Compounds 45 are obtained from the Curcuma genus for the first time,and compounds 1,2,3,and 6 are isolated from C.wenyujin for the first time.

关键词(KeyWords): 温莪术;化学成分;愈创木烷;吉玛烷;桉烷型;倍半萜
Curcuma wenyujin;chemical constituent;guaiane;germacrane;eudesmane;sesquiterpene

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作者(Author): 楼燕,何昊,魏星川,李雪改,陈丽霞,邱峰
LOU Yan,HE Hao,WEI Xing-chuan,LI Xue-gai,CHEN Li-xia,QIU Feng(School of Traditional Chinese Materia Medica

DOI: 10.14066/j.cnki.cn21-1349/r.2010.03.003

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