张天虹,赵春顺,林昀,何仲贵,章洪方,范岩
ZHANG Tian-hong1; ZHAO Chun-shun1; LIN Yun1; HE Zhong-gui1; ZHANG Hong-fang2; FAN Yan3 (1.School of Pharmacy;

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院
• 3:沈阳药科大学药学院
• 4:沈阳药科大学药学院

摘要(Abstract)：

目的考察不同质量浓度的羟丙基 β 环糊精对桂利嗪稳定性的影响。 方法采用HPLC法 ,测定波长为 2 5 4nm ,稳定性考察温度为 6 0、70、80、90、10 0℃。结果质量浓度在 1 6～ 6 4mg·L-1内线性关系良好 (r =0 9999) ,回收率平均值为 10 0 4 % ,RSD =0 5 2 % ,桂利嗪的降解速度常数k随羟丙基 β 环糊精质量浓度的增加而减小。 结论羟丙基 β 环糊精对桂利嗪有稳定作用 ,其作用随羟丙基 β 环糊精质量浓度的增加而增大。
Objective To investigate the effect of different concentrations (0～20%)of hydroxypropyl-β-cyclodextrin on the stability of cinnarizine.Methods The samples were determined by HPLC.The wavelength of the detector was set at 254 nm.The temperatures of the stability test were 60,70,80,90, 100 ℃.Results The linear calibration curves were obtained in the concentration range of 1.6～ 64 mg·L -1 (r= 0.999 9).The mean recovery was 100.3%,RSD=0.52%.The degradation rate constant of cinnarizine was decreased in the high concentration of hydroxypropyl-β-cyclodextrin solutions.Conclusion The hydroxypropyl-β-cyclodextrin can improve the stability of cinnarizine and the stability of cinnarizine can be improved along with the increasing of the hydroxypropyl-β-cyclodextrin concentration.

关键词(KeyWords)： 桂利嗪;羟丙基-β-环糊精;稳定性;高效液相色谱法;降解速度常数
cinnarizine; hydroxypropyl-β-cyclodextrin; stability; HPLC; degradation rate constant

Abstract:

Keywords:

基金项目(Foundation): 国家“九五”攻关 (96 - 90 2 - 0 2 - 0 9)

作者(Authors): 张天虹,赵春顺,林昀,何仲贵,章洪方,范岩
ZHANG Tian-hong1; ZHAO Chun-shun1; LIN Yun1; HE Zhong-gui1; ZHANG Hong-fang2; FAN Yan3 (1.School of Pharmacy;

参考文献(References)：

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