由立红,邹英华,景秋芳,胡良才
You Li hong 1; ZOU Ying hua 1; JING Qiu fnag 2; HU Liang cai 2 (1 The Department of Pharmacy of Dalian Hospital for Gynecology and Obstetrics Liaoning 116023;

• 1:大连妇产医院药剂科
• 2:大连妇产医院药剂科
• 3:沈阳药科大学药学系
• 4:沈阳药科大学药学系 辽宁大连116033

摘要(Abstract)：

目的利用甲壳胺 海藻酸钠的聚合物作为新型缓控释制剂的复合骨架材料 ,并对其性质及影响因素进行研究。方法利用天然高分子材料甲壳胺 (CS) (阳离子型 )与海藻酸钠 (AL) (阴离子型 )模拟在体内条件下形成聚电解质复合物。通过DTA及IR图谱的峰值变化证明这种复合物确实存在 ,形成的关键是控制好两种电解质的比例。结果当WCS∶WAL=2∶3时 ,反应最完全。利用制成的聚电解质复合物 ,制备葛根素缓释复合骨架片 ,缓释效果符合中国药典规定。结论甲壳胺 海藻酸钠形成的复合物可以做缓、控释制剂的骨架材料。
Objective To study on the property and influencing factors of a novel sustained release compound matrix polymerized by chitosan(CS) and sodium alginate(AL).Methods Polyelectrolite was formed under siumulated condition(gastie juice)using natural macromolecular material such as CS as a cation and AL as an anion According to DTA and IR,it was proved that this compound really existed and the proper ratio of the electrolytes was crucial to form this compound.Results The reaction was complete when the weight ratio of CS to AL was 2∶3.The sustained release property of puerarin loaded compound matrix sustained release tablets was coincident with CH.P.2000.Conclusions The compound prepared with CS and AL could be used as matrix material for sustained release formulations.

关键词(KeyWords)： 甲壳胺;海藻酸钠;聚电解质复合物;葛根素;缓释片
CS; AL; polyelectrolite; puerarin; sustained release

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 由立红,邹英华,景秋芳,胡良才
You Li hong 1; ZOU Ying hua 1; JING Qiu fnag 2; HU Liang cai 2 (1 The Department of Pharmacy of Dalian Hospital for Gynecology and Obstetrics Liaoning 116023;

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