(±)-2-[4-(1-氧代-2异吲哚啉基)苯基]丁酸乙酯的合成Synthesis of(±)ethyl 2-[4-(1-oxo-2-isoindolinyl) phenyl]butyrate
王松青,刘秀杰,郑连友
WANG Song qing 1; LIU Xiu jie 2; ZHENG Lian you 1 (1 Department of Pharmaceutics;
摘要(Abstract)：
以 (± ) 2 [4 (1,3 二氧代 2异吲哚啉基 )苯基 ]丁酸为原料合成了 (± ) 2 [4 (1 氧代 2异吲哚啉基 )苯基 ]丁酸乙酯 ,收率为 77 4% ,该合成法未见文献报道
In this paper,the synthesis of(±)ethyl 2 [4 (1 oxo 2 isoindolinyl)phenyl]butyrate using 2 [4 (1,3 dioxo 2 isoindolinyl)phenyl]butyric acid as the starting material was described. This synthetic method has not been reported up to now and the yield is good (77 4%).
关键词(KeyWords)：
吲哚布芬;合成;酯化
indobufen derivatives; synthesis;esterification
基金项目(Foundation):
作者(Authors):
王松青,刘秀杰,郑连友
WANG Song qing 1; LIU Xiu jie 2; ZHENG Lian you 1 (1 Department of Pharmaceutics;
参考文献(References)：
- [1]LyndaRW ,AndrewF ,MicaelaMB .Indobufenareviewofitspharmacokincticandpharmacodynamicproperticsandtherapeuticefficacyincerebral,peripheralandcornaryvasculardisease [J].Drugs ,1992 ,44 (3) :44 5～46 4.
- [2 ]国家医药管理局医药工业情报中心站 ,国际医药服务公司 .世界新药 [M ].北京 :中国医药科技出版社 ,1987.
- [3]NanniniG ,GiraldiPN ,Molgora ,etal.Newanale gesic antiinflammatorydrugs ,1 oxo 2 substitutedisoin dolinderivatives [J].Arznein Forsch ,1973 ,2 3 (8) :10 90～ 110 0 .
- [4 ]高学民 ,陈月轩 ,陈伟兴 .抗凝药吲哚布芬的合成[J].中国医药工业杂志 ,1989,2 0 (1) :486～ 487.
- [5 ]郑庚修 ,王秋芬 .吲哚布芬的制备工艺 [J].中国医药工业杂志 ,1991,2 2 (7) :2 91～ 2 93 .
- [6 ]GiraldPN ,NanniniG ,LogemannW .etal .Analgesicandantiinflammatory 1 isoindolinonederivatives [P].GerPat:2 15 45 2 5 ,1972 0 5 15 .