沈阳药科大学学报

2002, (01) 38-40

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HPLC法测定硝苯地平阿替洛尔缓释双层片中2组分含量
Quantitative determination of nifedipine and atenolol in their sustained release two-layer tablets by HPLC

王中彦,唐星,侯景刚,潘春明,魏晓军
WANG Zhong yan 1; TANG Xing 1; HOU Jing gang 2; PAN Chun ming 2; WEI Xiao jun 3 (1 School of Pharmacy;

摘要(Abstract):

目的测定硝苯地平阿替洛尔缓释双层片中 2组分含量。方法采用ODS(Hypersil,5 μm,4 6mm× 2 0 0mm)为填充剂 ,甲醇 水 磷酸 ( 70∶30∶0 1 )流动相的高效液相色谱法。结果硝苯地平和阿替洛尔线性分别为 0 4 0~ 1 2 0 μg ,0 80~ 2 38μg;回收率分别为 99 8%(RSD =1 0 %) ,99 9%(RSD =0 5 %)。结论该方法为评价该制剂的质量提供了可靠的方法
Objective Selecting a method is to determine nifedipine and atenolol in their sustained release two layer tablets.Method A method was establised for the quantitative determination of nifedipine and atenolol in their sustained release two layer tablets by HPLC. With a 4 6 mm×200 mm column packing of 5 μm Spherisorb C 18 used as the stationary phase,a mixture of methanol,water and phosphoric acid(70∶30∶0 1) used as the mobile phase.Result The method had a good linearity and correlation coefficient:nifedipine was between 0 40~1 20 μg,atenolol was between 0 80~ 2 38 μg .The recoveries were 99 7% and 99 9%,RSD was 0 84% and 0 43% respectively.Conclusion The method can evaluate well and truly quality of this preparation.

关键词(KeyWords): 硝苯地平;阿替洛尔;缓释双层片;高效液相色谱法
nifedipine; atenolol; sustained release two layer tablets; HPLC

Abstract:

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作者(Authors): 王中彦,唐星,侯景刚,潘春明,魏晓军
WANG Zhong yan 1; TANG Xing 1; HOU Jing gang 2; PAN Chun ming 2; WEI Xiao jun 3 (1 School of Pharmacy;

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