徐伟,辛菲,刘明,沙沂,方瑾,李玉山
XU Wei1,XIN Fei1,LIU Ming1,SHA Yi1,FANG Jin2,LI Yu-shan1(1.School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院
• 2:中国医科大学基础医学院

摘要(Abstract)：

目的研究马鞭草中裂环环烯醚萜苷类成分。方法采用反复硅胶柱色谱、Sephadex LH-20柱色谱和半制备高效液相色谱等方法进行分离纯化,依据MS、1D和2D NMR(1H-1H COSY、HMQC和HMBC)进行结构鉴定。结果从马鞭草乙醇提取物的正丁醇可溶部分分离得到5个裂环环烯醚萜苷类化合物,分别鉴定为三叶草苷(trifloroside,1)、macrophylloside(2)、3′-acetylsweroside(3)、当药苦苷(swertiamarin,4)和龙胆苦苷(gentiopicroside,5)。结论化合物1~4为首次从马鞭草属植物中分离得到。
Objective To study the secoiridoid glycoside constituents of Verbena officinalis L.Methods The compounds were isolated by silica gel,Sephadex LH-20 and semiprep.HPLC column chromatography and MS,1D and 2D NMR(1H-1H COSY,HMQC and HMBC)were employed for the structural identification.Results Compounds 15 were obtained from the n-BuOH soluble constituents of Verbena officinalis and their structures were identified as trifloroside(1),macrophylloside(2),3′-acetylsweroside(3),swertiamarin(4)and gentiopicroside(5),which are secoiridoid glycosides.Conclusions Compounds 14 are isolated from the genus Verbena for the first time.

关键词(KeyWords)： 马鞭草;裂环环烯醚萜苷类;化学成分;结构鉴定
Verbena officinalis L.;secoiridoid glycoside;chemical constituent;structure identification

Abstract:

Keywords:

基金项目(Foundation): 辽宁省教育厅科研基金资助项目(2004C073)

作者(Author): 徐伟,辛菲,刘明,沙沂,方瑾,李玉山
XU Wei1,XIN Fei1,LIU Ming1,SHA Yi1,FANG Jin2,LI Yu-shan1(1.School of Traditional Chinese Materia Medica

DOI: 10.14066/j.cnki.cn21-1349/r.2010.10.004

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