张晓书,韩瑞亭,高慧媛,李卫东,吴兆华
ZHANG Xiao-shu1,HAN Rui-ting2,GAO Hui-yuan1,LI Wei-dong1,WU Zhao-hua3(1.Key Laboratory of Structure-Based Drug Design & Discovery

• 1:沈阳药科大学教育部基于靶点的药物设计与研究重点实验室
• 2:黑龙江农业经济职业学院制药工程系
• 3:牡丹江医学院药学系

摘要(Abstract)：

目的对苦石莲中的化学成分做进一步研究。方法采用硅胶柱色谱、凝胶柱色谱和重结晶等多种方法分离纯化,根据理化性质及波谱学数据进行结构鉴定。结果分离得到9个化合物,分别鉴定为全反式-5-脱氧戊糖酸-γ-内酯(all-trans-5-deoxy-pentonic acid-γ-lactone,1)、腺苷(adeno-sine,2)、胡萝卜苷-6'-O-硬脂酸酯(daucosterol-6'-O-stearate,3)、7-acetoxybonducellpin C(4)、caesal-pinin K(5)、norcaesalpinin E(6)、neocaesalpin A(7)、neocaesalpin L(8)、neocaesalpin M(9)。结论化合物1、2为首次从云实属植物中分离得到,化合物3～5、7为首次从喙荚云实植物中分离得到。
Objective To study the chemical constituents from the seeds of Caesalpinia minax Hance.Methods Compounds were isolated by column chromatography on silica gel,Sephadex LH-20 together with recrystallization methods and identified by their physical-chemical properties and spectral analysis.Results Nine compounds were obtained and elucidated as:all-trans-5-deoxy-pentonic acid-γ-lactone(1),adenosine(2),daucosterol-6′-O-stearate(3),7-acetoxybonducellpin C(4),caesalpinin K(5),norcaesalpinin E(6),neocaesalpin A(7),neocaesalpin L(8)and neocaesalpin M(9),respectively.Conclusions Compounds 1 and 2 are isolated from Caesalpinia genus for the first time,compounds 3,4,5 and 7 are isolated from this plant for the first time.

关键词(KeyWords)： 喙荚云实;苦石莲;化学成分;结构鉴定
Caesalpinia minax Hance;Kushilian;chemical constituent;structure identification

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省自然科学基金资助项目(D200947);; 黑龙江省中医药管理局资助项目(10W72);; 辽宁省高等学校优秀人才支持计划资助项目(LJQ2011103)

作者(Author): 张晓书,韩瑞亭,高慧媛,李卫东,吴兆华
ZHANG Xiao-shu1,HAN Rui-ting2,GAO Hui-yuan1,LI Wei-dong1,WU Zhao-hua3(1.Key Laboratory of Structure-Based Drug Design & Discovery

DOI: 10.14066/j.cnki.cn21-1349/r.2012.02.009

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